Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSPA5 | P11021 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | HSPA2 | P54652 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10737592 | 0.93 | HSPA5 (0.44) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL9601722 | 0.90 | SCN9A (0.45) | HTTLMNATSHRMEN1KMT2A | |
| SCHEMBL10740580 | 0.90 | HTT (0.42) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10744027 | 0.90 | HTT (0.42) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10741576 | 0.90 | HSPA5 (0.47) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10739618 | 0.88 | HSPA5 (0.43) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10942295 | 0.88 | HTT (0.44) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL11620300 | 0.88 | HTT (0.44) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10659235 | 0.87 | HTT (0.43) | HTTLMNATSHRHSPA5MEN1 | |
| SCHEMBL10941363 | 0.87 | LMNA (0.43) | HTTLMNATSHRHSPA5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169755-B1 | 4-HYDROXY-3-QUINOLINE-CARBOXYLIC-ACID DERIVATIVES SUBSTITUTED AT 2 BY A NITROGEN-CONTAINING GROUP, THEIR PREPARATION, THEIR USE AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES | ROUSSEL-UCLAF (FR) | 1990-05-09 | — | — | EP | disclosed |