Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7315054 | 0.89 | L3MBTL1 (0.38) | PDE3BPDE3ASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL7313849 | 0.88 | L3MBTL1 (0.39) | PDE3BPDE3ASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL7320520 | 0.87 | PDE3B (0.47) | PDE3BPDE3AKDM4ECYP2C19ALDH1A1 | |
| SCHEMBL10375732 | 0.86 | PDE3B (0.39) | PDE3BPDE3ASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL10374677 | 0.86 | PDE3B (0.39) | PDE3BPDE3AL3MBTL1CASP6KMT2A | |
| SCHEMBL10374564 | 0.85 | PDE3B (0.40) | PDE3BPDE3ASMN1; SMN2POLBL3MBTL1 | |
| SCHEMBL7317245 | 0.84 | PDE3B (0.44) | PDE3BPDE3AL3MBTL1KDM4ECYP2D6 | |
| SCHEMBL10374533 | 0.80 | PDE3B (0.50) | PDE3BPDE3AKDM4ECYP2C19ALDH1A1 | |
| SCHEMBL10376782 | 0.80 | PDE3B (0.40) | PDE3BPDE3AL3MBTL1CASP6MAPT | |
| SCHEMBL7307953 | 0.80 | PDE3B (0.42) | PDE3BPDE3ASMN1; SMN2POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116948-B1 | (2-OXO-1,2,3,5-TETRAHYDROIMIDAZO-(2,1-B)QUINAZOLINYL)-OXYALKYL-AMIDES | SYNTEX (U.S.A.) INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4663320-A | ANTITUMOR AGENTS, ANTICOAGULANTS | SYNTEX (U.S.A.) INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4551459-A | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides | SYNTEX (U.S.A.) INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4490371-A | ANTICOAGULANTS, PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0116948-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides | SYNTEX (U.S.A.) INC. (US) | 1984-08-29 | — | — | EP | disclosed |