Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.57 |
| ▸ | FAAH | O00519 | 10/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384599 | 0.90 | CYP3A4 (0.58) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1039932 | 0.89 | CYP3A4 (0.62) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1039557 | 0.87 | CYP3A4 (0.53) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1040115 | 0.87 | FAAH (0.56) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036113 | 0.85 | FAAH (0.58) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036643 | 0.83 | CYP3A4 (0.62) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1040265 | 0.82 | CYP3A4 (0.47) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1077445 | 0.82 | CYP3A4 (0.67) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1038006 | 0.82 | SMN1; SMN2 (0.42) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1960779 | 0.82 | CYP3A4 (0.64) | CYP3A4CYP2D6FAAHGABRA1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276735-A1 | ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | Pfizer Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009127944-A1 | ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | PFIZER INC. (US) | 2009-10-22 | — | — | WO | disclosed |