Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | IAPP | P10997 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA3 | P07451 | 2/20 | 0.40 |
| ▸ | CA4 | P22748 | 2/20 | 0.40 |
| ▸ | CA6 | P23280 | 2/20 | 0.40 |
| ▸ | CA5A | P35218 | 2/20 | 0.40 |
| ▸ | CA7 | P43166 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10375966 | 1.00 | KDM4E (0.42) | KDM4EALDH1A1SMN1; SMN2ACACBIAPP | |
| SCHEMBL16832018 | 0.92 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2ACACBHSD17B10 | |
| SCHEMBL16832019 | 0.92 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2ACACBHSD17B10 | |
| SCHEMBL16831964 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL16831963 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL10375147 | 0.84 | TTR (0.51) | APPCA12CA1CA2CA7 | |
| SCHEMBL10375148 | 0.84 | TTR (0.51) | APPCA12CA1CA2CA7 | |
| SCHEMBL10375030 | 0.79 | ACACB (0.39) | ALDH1A1ACACBKMT2AHDAC3HDAC1 | |
| SCHEMBL16831652 | 0.77 | TUBB4A (0.51) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL16831650 | 0.77 | TUBB4A (0.51) | KDM4EALDH1A1SMN1; SMN2HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117345-B1 | AMINOPYRIMIDINONES AS HISTAMINE H2-ANTAGONISTS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1990-02-28 | — | — | EP | disclosed |
| US-4540699-A | N-Substituted pyridinones having histamine H2 -antagonist activity | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-09-10 | — | — | US | disclosed |