Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 14/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.41 |
| ▸ | P2RY12 | Q9H244 | 8/20 | 0.41 |
| ▸ | PDE2A | O00408 | 7/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7316875 | 0.99 | PDE3B (0.42) | PDE3BPDE3AP2RY12PDE2ATHRA | |
| SCHEMBL10376932 | 0.96 | PDE3B (0.44) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10377093 | 0.96 | PDE3B (0.43) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10374909 | 0.94 | PDE3B (0.44) | PDE3BPDE3AP2RY12PDE2ASIRT5 | |
| SCHEMBL10375775 | 0.93 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10376853 | 0.92 | PDE3B (0.48) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL7312013 | 0.91 | PDE3B (0.41) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10376785 | 0.90 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10374868 | 0.90 | PDE3B (0.47) | PDE3BPDE3AP2RY12PDE2AHPGD | |
| SCHEMBL10376736 | 0.90 | PDE3B (0.45) | PDE3BPDE3AP2RY12PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116948-B1 | (2-OXO-1,2,3,5-TETRAHYDROIMIDAZO-(2,1-B)QUINAZOLINYL)-OXYALKYL-AMIDES | SYNTEX (U.S.A.) INC. (US) | 1990-01-03 | — | — | EP | disclosed |
| US-4663320-A | ANTITUMOR AGENTS, ANTICOAGULANTS | SYNTEX (U.S.A.) INC. (US) | 1987-05-05 | — | — | US | disclosed |
| US-4551459-A | Method of treating heart failure using (2-oxo-1,2,3,5-tetrahydroimidazo-[2,1-b]quinazolinyl)oxyalkylamides | SYNTEX (U.S.A.) INC. (US) | 1985-11-05 | — | — | US | disclosed |
| US-4490371-A | ANTICOAGULANTS, PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0116948-A2 | (2-Oxo-1,2,3,5-tetrahydroimidazo-(2,1-b)quinazolinyl)-oxyalkyl-amides | SYNTEX (U.S.A.) INC. (US) | 1984-08-29 | — | — | EP | disclosed |