Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.43 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377424 | 0.91 | KDM4E (0.57) | KDM4ERAB9ATP53HSD17B10KMT2A | |
| SCHEMBL10375282 | 0.86 | ALDH1A1 (0.55) | RAB9AKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL11012629 | 0.84 | SMN1; SMN2 (0.54) | KDM4ERAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL10377541 | 0.84 | NPC1 (0.50) | RAB9ATP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL10377358 | 0.84 | NPC1 (0.50) | RAB9ATP53KMT2AMEN1ALDH1A1 | |
| SCHEMBL10754019 | 0.84 | POLB (0.44) | RAB9AKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10375355 | 0.83 | ALDH1A1 (0.53) | KDM4ERAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL10376717 | 0.82 | ALDH1A1 (0.45) | RAB9AKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10375511 | 0.82 | ALDH1A1 (0.46) | RAB9AKMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL10376552 | 0.82 | NPC1 (0.48) | KDM4ERAB9AKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0169712-B1 | NEW PYRIMIDINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND COMPOSITION CONTAINING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-12-12 | — | — | EP | disclosed |
| US-4698340-A | TREATMENT OF CEREBROVASCULAR DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-06 | — | — | US | disclosed |
| EP-0169712-A2 | New pyrimidine derivatives, processes for preparation thereof and composition containing the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-29 | — | — | EP | disclosed |