Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | PDE4A | P27815 | 6/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629927 | 0.91 | PDE4A (0.48) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL10378372 | 0.90 | HPGD (0.47) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL9629754 | 0.90 | HPGD (0.47) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL10379024 | 0.88 | PKM (0.45) | HPGDCYP2C19CYP1A2ALDH1A1KAT2B | |
| SCHEMBL9629709 | 0.85 | HPGD (0.40) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL9630048 | 0.85 | KAT2B (0.42) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL9630898 | 0.84 | HPGD (0.49) | HPGDCYP2C19CYP1A2ALDH1A1PDE4B | |
| SCHEMBL10377155 | 0.82 | CYP1A2 (0.45) | HPGDCYP2C19CYP1A2CYP2C9ALDH1A1 | |
| SCHEMBL10377462 | 0.82 | PDE4B (0.42) | HPGDCYP2C19CYP1A2PDE4BPDE4D | |
| SCHEMBL9629788 | 0.82 | KAT2B (0.45) | HPGDALDH1A1KAT2BPDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |