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PKM

Pyruvate kinase PKM · P14618 · PKM on Sugi Atlas →

1,086,186 patent compounds predicted against PKM, 695,805 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Parthenolide Parthenolide (SCHEMBL8219) 1.00 13/20
Parthenolide Parthenolide (SCHEMBL8220) 1.00 13/20
SCHEMBL16781 SCHEMBL16781 0.71 10/20
SCHEMBL17670 SCHEMBL17670 0.52 8/20
SCHEMBL14803 SCHEMBL14803 0.65 6/20
SCHEMBL12041 SCHEMBL12041 0.75 5/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL16597) 0.74 5/20
SCHEMBL14751 SCHEMBL14751 0.73 5/20
SCHEMBL12129 SCHEMBL12129 0.69 5/20
Carbendazim Carbendazim (SCHEMBL21051) 0.64 5/20
SCHEMBL11684 SCHEMBL11684 0.64 5/20
SCHEMBL16809 SCHEMBL16809 0.63 5/20
SCHEMBL11928 SCHEMBL11928 0.63 5/20
SCHEMBL14840 SCHEMBL14840 0.62 5/20
SCHEMBL12235 SCHEMBL12235 0.60 5/20
SCHEMBL11676 SCHEMBL11676 0.60 5/20
SCHEMBL14838 SCHEMBL14838 0.58 5/20
SCHEMBL18668 SCHEMBL18668 0.47 5/20
SCHEMBL17508 SCHEMBL17508 0.45 5/20
SCHEMBL18403 SCHEMBL18403 0.44 5/20

Clinical trials — most relevant to PKM by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
To Assess Safety of Mitapivat and Provide Proof of Concept of the Efficacy of the Drug in Patients With RBC Membranopathies or CDAII. PHASE2RECRUITING
Safety and Efficacy of Mitapivat Sulfate in Adult Patients With Erythrocyte Membranopathies PHASE2NOT_YET_RECRUITING
Clinical Trial to Evaluate the Efficacy of Gene Therapy for Pyruvate Kinase Deficiency PHASE2SUSPENDED
Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI) PHASE2RECRUITING
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
A Dose-Finding Study of AG-348 in Sickle Cell Disease EARLY_PHASE1COMPLETED
Pyruvate Kinase Deficiency Natural History Study nanCOMPLETED
Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease nanRECRUITING
Fluorodeoxyglucose Positron Emission Tomography (FDG PET) Findings in Patients With Phenylketonuria Before and After KUVAN Therapy nanCOMPLETED
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4 nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Pyruvate Kinase Deficiency Epidemiological Study (PIECE) nanCOMPLETED
Alternative Substrates in the Critically Ill Subject nanCOMPLETED
Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU) nanRECRUITING
Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis nanCOMPLETED
The Role of Pyruvate Kinase M2 in Growth, Invasion and Drug Resistance in Human Urothelial Carcinoma nanUNKNOWN
UTSW HP [13-C] Pyruvate Injection in HCM nanCOMPLETED
Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms nanCOMPLETED
McArdle Disease Treatment by Ketogenic Diet nanCOMPLETED
Regulation of Lymphocyte Anti-tumor Response in Metastatic Patients Treated With the mTOR Inhibitor Everolimus nanCOMPLETED
Metabolic Remodeling in Pulmonary Arterial Hypertension (PAH) nanCOMPLETED
Pyruvate Kinase Deficiency Global Longitudinal Registry nanACTIVE_NOT_RECRUITING
Energy Requirements in Mitochondrial Disease nanCOMPLETED
Impact of Phenylalanine Elevations on Brain and Cognition in Adult PKU Carriers nanRECRUITING
Evaluation of PKU UP nanCOMPLETED
Abnormalities in the Effects of Insulin and Exercise on Glucose- and Lipid Metabolism in Obesity and Type 2 Diabetes nanCOMPLETED
Oxaloacetate Supplementation for Emotional PMS nanCOMPLETED
Gall Bladder Status Among Children With Chronic Haemolytic Anemia nanUNKNOWN
The Effect of Ketone Esters on Forearm Glucose Metabolism nanACTIVE_NOT_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PKM binder may also engage these)

ProteinNameSimilarity
Q92122 — 1.000 Q92122 →
P52480 — 1.000 P52480 →
P11980 — 1.000 P11980 →
P11974 — 1.000 P11974 →
Q5NVN0 — 1.000 Q5NVN0 →
Q42954 — 1.000 Q42954 →
P00548 — 1.000 P00548 →
P11979 — 1.000 P11979 →
O65595 — 1.000 O65595 →
Q12669 — 1.000 Q12669 →
O62619 — 0.999 O62619 →
P22360 — 0.999 P22360 →
PKLR Pyruvate kinase PKLR 0.998 landscape →
P53657 — 0.998 P53657 →
Q6FIS9 — 0.998 Q6FIS9 →
P30616 — 0.998 P30616 →
P30615 — 0.998 P30615 →
Q42806 — 0.997 Q42806 →
P31865 — 0.997 P31865 →
P12928 — 0.997 P12928 →
P00549 — 0.997 P00549 →
Q875S4 — 0.996 Q875S4 →
O44006 — 0.996 O44006 →
Q875Z9 — 0.995 Q875Z9 →
Q759A9 — 0.995 Q759A9 →
Q10208 — 0.995 Q10208 →
P30614 — 0.994 P30614 →
Q7RVA8 — 0.993 Q7RVA8 →
Q27686 — 0.993 Q27686 →
P22200 — 0.992 P22200 →