Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.32 |
| ▸ | HTR1D | P28221 | 4/20 | 0.32 |
| ▸ | HTR1B | P28222 | 4/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274719 | 0.94 | REN (0.36) | RENCYP3A4TSHRMAPTCHRM1 | |
| SCHEMBL1037840 | 0.89 | REN (0.33) | RENPPARGPPARA | |
| SCHEMBL3949181 | 0.85 | REN (0.39) | RENCYP3A4TSHRPPARGPPARA | |
| SCHEMBL3906325 | 0.84 | REN (0.40) | RENCYP3A4TSHRPPARGPPARA | |
| SCHEMBL1037801 | 0.84 | REN (0.39) | RENCYP3A4TSHRPPARGPPARA | |
| SCHEMBL1037108 | 0.83 | REN (0.35) | REN | |
| SCHEMBL1034992 | 0.81 | MAPT (0.39) | RENCYP3A4TSHRMAPTCHRM1 | |
| SCHEMBL3911082 | 0.81 | MAPT (0.40) | RENCYP3A4TSHRMAPTCHRM1 | |
| SCHEMBL1036573 | 0.81 | MAPT (0.41) | RENCYP3A4TSHRMAPTCHRM1 | |
| SCHEMBL2682976 | 0.80 | REN (0.36) | RENCYP3A4TSHRMAPTHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049514-B1 | NITRATE ESTERS OF PIPERIDINES | NOVARTIS AG (CH) | 2011-01-26 | — | — | EP | disclosed |