Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 2/20 | 0.51 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629787 | 0.97 | EPHB4 (0.52) | EPHB4KAT2BMAPTTHRBPOLB | |
| SCHEMBL10377092 | 0.94 | EPHB4 (0.48) | EPHB4KAT2BMAPTTHRBPOLB | |
| SCHEMBL9629703 | 0.90 | PKM (0.45) | EPHB4KAT2BMAPTTHRBPOLB | |
| SCHEMBL10653938 | 0.87 | EPHB4 (0.52) | EPHB4KAT2BMAPTTHRBPOLB | |
| SCHEMBL10377111 | 0.86 | MAPT (0.47) | EPHB4MAPTPDE4BPDE4DALOX5 | |
| SCHEMBL10659605 | 0.85 | PDE4B (0.41) | EPHB4MAPTPDE4BPDE4DALOX5 | |
| SCHEMBL9629723 | 0.85 | FEN1 (0.48) | KAT2BMAPTL3MBTL1PDE4BPDE4D | |
| SCHEMBL10378415 | 0.84 | EPHB4 (0.44) | EPHB4KAT2BMAPTTHRBPOLB | |
| SCHEMBL9628920 | 0.83 | MAPT (0.46) | EPHB4MAPTL3MBTL1PDE4BPDE4D | |
| SCHEMBL9628888 | 0.83 | PKM (0.47) | KAT2BMAPTTHRBSMN1; SMN2PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0127135-B1 | FUSED TRICYCLIC DERIVATIVES OF NAPHTHYRIDINONE AND PYRIDONE AND THE CORRESPONDING THIONES | SCHERING CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4740511-A | ANTIALLERGENS, ANTIINFLAMMATORY, ANTIULCER AGENTS | SCHERING CORPORATION (US) | 1988-04-26 | — | — | US | disclosed |
| US-4680298-A | Tricyclic anti-allergy and use as anti-inflammatory agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| US-4680297-A | Tricyclic positive inotropic agents | SCHERING CORPORATION (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0127135-A2 | Fused tricyclic derivatives of naphthyridinone and pyridone and the corresponding thiones | SCHERING CORPORATION (US) | 1984-12-05 | — | — | EP | disclosed |