Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1036941 | 0.93 | CYP3A4 (0.40) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1037033 | 0.88 | CYP3A4 (0.42) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1075874 | 0.84 | CYP3A4 (0.43) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1037321 | 0.82 | POLB (0.33) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1037320 | 0.82 | POLB (0.33) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL6522790 | 0.81 | PDE2A (0.33) | FAAHOGAPOLB | |
| SCHEMBL1011604 | 0.81 | CYP3A4 (0.49) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1075244 | 0.81 | CYP3A4 (0.45) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036429 | 0.81 | CYP3A4 (0.42) | CYP3A4CYP2D6FAAHGABRA1ADRA2C | |
| SCHEMBL1036041 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6FAAHGABRA1ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276738-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | Pfizer Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009127943-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | PFIZER INC. (US) | 2009-10-22 | — | — | WO | disclosed |