Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 5/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | OGA | O60502 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1037042 | 0.93 | CYP3A4 (0.42) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1033477 | 0.88 | CYP3A4 (0.43) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1037994 | 0.84 | CYP3A4 (0.42) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1075244 | 0.84 | CYP3A4 (0.45) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1033128 | 0.82 | GPR119 (0.33) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1033127 | 0.82 | GPR119 (0.33) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL6515954 | 0.81 | ACACB (0.34) | CYP3A4CYP2D6FAAHOGAGPR119 | |
| SCHEMBL1033106 | 0.81 | CYP3A4 (0.44) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1036417 | 0.81 | CYP3A4 (0.46) | CYP3A4CYP2D6FAAHCNR2GABRA1 | |
| SCHEMBL1962310 | 0.80 | FAAH (0.59) | CYP3A4CYP2D6FAAHCNR2GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2276738-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | Pfizer Inc. (US) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009127943-A1 | ETHER BENZYLIDENE PIPERIDINE 5-MEMBERED ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS | PFIZER INC. (US) | 2009-10-22 | — | — | WO | disclosed |