Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.58 |
| ▸ | CNR2 | P34972 | 5/20 | 0.52 |
| ▸ | CNR1 | P21554 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | THRA | P10827 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL10379935 | 0.96 | IDO1 (0.54) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL2023756 | 0.89 | IDO1 (0.71) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL30003085 | 0.89 | IDO1 (0.71) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL10379934 | 0.84 | CNR2 (0.51) | CNR2CNR1MEN1KMT2AHIF1A | |
| SCHEMBL2023403 | 0.81 | IDO1 (0.69) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL30003094 | 0.81 | IDO1 (0.69) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL8665665 | 0.80 | IDO1 (0.67) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL30003478 | 0.80 | IDO1 (0.67) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL991493 | 0.79 | IDO1 (0.56) | IDO1CNR2CNR1MEN1KMT2A | |
| SCHEMBL29502706 | 0.79 | CNR1 (0.58) | IDO1CNR2CNR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990006372-A1 | SUBSTRATES FOR PEROXIDASE ASSAYING | MICROPROBE CORPORATION (US) | 1990-06-14 | — | — | WO | disclosed |