Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 3/20 | 0.55 |
| ▸ | ICMT | O60725 | 9/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10380473 | 1.00 | ADAM17 (0.55) | ADAM17ICMTSIRT2KMT2APLA2G2A | |
| SCHEMBL9584378 | 1.00 | ADAM17 (0.55) | ADAM17ICMTSIRT2KMT2APLA2G2A | |
| Hydrochloric Acid SCHEMBL9583871 | 0.99 | ADAM17 (0.54) | ADAM17ICMTSIRT2KMT2APLA2G2A | |
| Hydrochloric Acid SCHEMBL9583865 | 0.99 | ADAM17 (0.54) | ADAM17ICMTSIRT2KMT2APLA2G2A | |
| SCHEMBL9585459 | 0.95 | ADAM17 (0.51) | ADAM17ICMTALDH1A1LMNAHTR6 | |
| SCHEMBL9584364 | 0.91 | ADAM17 (0.58) | ADAM17ICMTKMT2AALDH1A1LMNA | |
| Water SCHEMBL10380911 | 0.90 | ADAM17 (0.57) | ADAM17ICMTKMT2AALDH1A1LMNA | |
| Water SCHEMBL10380909 | 0.90 | ADAM17 (0.57) | ADAM17ICMTKMT2AALDH1A1LMNA | |
| SCHEMBL9583769 | 0.88 | KMT2A (0.54) | ADAM17KMT2APLA2G2AALDH1A1LMNA | |
| SCHEMBL9583775 | 0.88 | KMT2A (0.54) | ADAM17KMT2APLA2G2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | claimed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | claimed |