ADAM17 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Marimastat (SCHEMBL34033)	1.00	13/20
Marimastat (SCHEMBL134999)	1.00	13/20
Prinomastat (SCHEMBL115696)	1.00	12/20
SCHEMBL26484	1.00	10/20
SCHEMBL136238	1.00	10/20
SCHEMBL136239	1.00	10/20
SCHEMBL25833	1.00	9/20
SCHEMBL138143	1.00	9/20
SCHEMBL138144	1.00	9/20
SCHEMBL421106	0.47	8/20
SCHEMBL58761	0.39	8/20
SCHEMBL58754	0.35	8/20
SCHEMBL58755	0.35	8/20
SCHEMBL58126	0.34	8/20
SCHEMBL88914	0.33	8/20
SCHEMBL56831	0.50	7/20
SCHEMBL88936	0.32	7/20
SCHEMBL57913	0.31	7/20
SCHEMBL88598	0.31	7/20
SCHEMBL58365	0.41	6/20

Clinical trials — most relevant to ADAM17 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Estimation of MMP-8 Levels in GCF and Serum and Its Correlation With Wound Healing and Clinical Outcomes After Coronally Advanced Flap and Subepithelial Connective Tissue Graft for Root Coverage in Recession Defects: A CLINICO-BIOCHEMICAL STUDY	PHASE4	SUSPENDED
Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome Treatment	PHASE3	NOT_YET_RECRUITING
Sputum Matrix Metalloproteinases (MMP) mRNA and Montelukast	PHASE2	COMPLETED
The Role of Matrix Metalloproteinases (MMPs) in Orthodontic Tooth Movement	PHASE1	COMPLETED
A Phase I Study of Oral COL-3 (NSC-683551), a Matrix Metalloproteinase Inhibitor, in Patients With Refractory Metastatic Cancer	PHASE1	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Exercise and the Receptor for Advanced Glycation End Products (RAGE)	nan	COMPLETED
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia	nan	UNKNOWN
Infection, Sepsis and Meningitis in Surinamese Neonates	nan	COMPLETED
Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects	nan	AVAILABLE
Association Between Matrix Metalloproteinase-2 Gene Polymorphism rs243865 and Susceptibility to Cataract Development	nan	COMPLETED
Apoptotic Changes in Gingiva Caused by Smoking	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Salivary Markers in Periodontal Disorders	nan	COMPLETED
Apoptosis Markers in Aggressive Periodontitis	nan	COMPLETED
Role of Extracellular Matrix in the Development of Airway Remodeling in Asthma	nan	UNKNOWN
Sirtuin1 in COVID19 Patients	nan	UNKNOWN
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy	nan	COMPLETED
Pharmacokinetics of Low Molecular Weight Heparin in Cancer Patients	nan	COMPLETED
Periodontal Health in Post COVID-19 Patients	nan	UNKNOWN
Circulating Markers for Ischemic Heart Disease	nan	RECRUITING
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Plasma Levels of Matrix Metalloproteinases (MMPs) and Degree of DNA Fragmentation in Pseudoexfoliation (PEX) Glaucoma	nan	COMPLETED
Role of Circulating MicroRNAs in Pathogenesis of Aneurysms of the Abdominal and Thoracic Aorta - Study Micro AAA	nan	UNKNOWN
Detection of Cancer-Specific Active Proteases in Blood Via Fluorescence	nan	WITHDRAWN
Peri-implantitis and MMP-8	nan	COMPLETED
Utility of Presepsin in Children Sepsis	nan	UNKNOWN
Biomarkers in Post Thrombotic Syndrome	nan	COMPLETED
Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial	nan	COMPLETED
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery	nan	ENROLLING_BY_INVITATION

Related proteins — ESM-2 sequence neighbours (a ADAM17 binder may also engage these)

Protein	Name	Similarity
Q9Z1K9	—	1.000	Q9Z1K9 →
Q9Z0F8	—	1.000	Q9Z0F8 →
O77636	—	1.000	O77636 →
O77633	—	0.995	O77633 →
G5EDW5	—	0.993	G5EDW5 →
ADAM10	Disintegrin and metalloproteinase domain-containing protein 10	0.993	landscape →
Q10743	—	0.993	Q10743 →
Q8JIY1	—	0.993	Q8JIY1 →
Q94316	—	0.993	Q94316 →
Q10741	—	0.992	Q10741 →
Q5W7F3	—	0.992	Q5W7F3 →
O35598	—	0.991	O35598 →
Q93105	—	0.990	Q93105 →
G5EFD9	—	0.990	G5EFD9 →
P86392	—	0.990	P86392 →
O18016	—	0.990	O18016 →
B5AJT4	—	0.989	B5AJT4 →
G5EFD5	—	0.989	G5EFD5 →
G5ECS8	—	0.989	G5ECS8 →
B5AJT3	—	0.989	B5AJT3 →
D5FM37	—	0.988	D5FM37 →
V9ZAY0	—	0.988	V9ZAY0 →
O73798	—	0.988	O73798 →
O35312	—	0.987	O35312 →
Q8BH35	—	0.987	Q8BH35 →
E9Q6D8	—	0.987	E9Q6D8 →
B4F6N6	—	0.987	B4F6N6 →
Q20930	—	0.987	Q20930 →
Q8W4J3	—	0.987	Q8W4J3 →
Q9WTR0	—	0.987	Q9WTR0 →