Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | FNTA | P49354 | 1/20 | 0.47 |
| ▸ | FNTB | P49356 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9584716 | 1.00 | KMT2A (0.57) | KMT2AADAM17HDAC6HDAC10HDAC1 | |
| Hydrochloric Acid SCHEMBL10380914 | 0.99 | KMT2A (0.59) | KMT2AADAM17HDAC6HDAC10HDAC1 | |
| Hydrochloric Acid SCHEMBL10380913 | 0.99 | KMT2A (0.59) | KMT2AADAM17HDAC6HDAC10HDAC1 | |
| SCHEMBL9583775 | 0.87 | KMT2A (0.54) | KMT2AADAM17HDAC6HDAC10HDAC1 | |
| SCHEMBL9583769 | 0.87 | KMT2A (0.54) | KMT2AADAM17HDAC6HDAC10HDAC1 | |
| SCHEMBL9584105 | 0.84 | KMT2A (0.65) | KMT2AHDAC6HDAC10HDAC1HDAC8 | |
| SCHEMBL5870369 | 0.82 | LMNA (0.45) | KMT2AADAM17HDAC6HDAC10MMP2 | |
| SCHEMBL5870367 | 0.82 | LMNA (0.45) | KMT2AADAM17HDAC6HDAC10MMP2 | |
| SCHEMBL5870366 | 0.82 | LMNA (0.45) | KMT2AADAM17HDAC6HDAC10MMP2 | |
| SCHEMBL5869335 | 0.80 | KMT2A (0.57) | KMT2AADAM17HDAC6HDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375133-A1 | Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents | THE UPJOHN COMPANY (US) | 1990-06-27 | — | — | EP | claimed |
| WO-1990005721-A1 | ALPHA-AMINO-INDOLE-3-ACETIC ACIDS USEFUL AS ANTI-DIABETIC, ANTI-OBESITY AND ANTI-ATHEROSCLEROTIC AGENTS | THE UPJOHN COMPANY (US) | 1990-05-31 | — | — | WO | claimed |