Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lactulose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HBB | P68871 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | FGF1 | P05230 | 1/20 | 0.35 |
| ▸ | FGF2 | P09038 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.35 |
| ▸ | IGF2R | P11717 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactulose SCHEMBL18470690 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL18912 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL15942982 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL17241809 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL12787176 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL11892653 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL15942980 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL11890264 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL18479188 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 | |
| Lactulose SCHEMBL17623952 | 0.82 | MEN1 (1.00) | MEN1KMT2AALDH1A1TSHRPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990014823-A1 | METHOD OF TREATING CATABOLIC, GUT-ASSOCIATED PATHOLOGICAL PROCESSES AND IMPAIRED HOST DEFENSES | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1990-12-13 | — | — | WO | disclosed |