Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 8/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379112 | 0.91 | SCN9A (0.73) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10326013 | 0.87 | SCN9A (0.79) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10324794 | 0.78 | SCN9A (0.55) | SCN9ASCN5A | |
| SCHEMBL10325203 | 0.78 | SCN9A (0.54) | SCN9ASCN5A | |
| SCHEMBL10379940 | 0.78 | SCN9A (0.67) | SCN9ASCN5A | |
| SCHEMBL10379447 | 0.77 | SCN9A (0.69) | SCN9ASCN5A | |
| SCHEMBL10379740 | 0.75 | SCN9A (0.77) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| SCHEMBL10379494 | 0.75 | SCN9A (0.79) | SCN9ASCN5A | |
| Pf-05241328 SCHEMBL10324699 | 0.75 | SCN9A (1.00) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 | |
| Pf-05241328 SCHEMBL30275387 | 0.75 | SCN9A (1.00) | SCN9ASCN5ACYP2C8CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012095781-A1 | INDAZOLE DERIVATIVES AS SODIUM CHANNEL INHIBITORS | PFIZER LIMITED (GB) | 2012-07-19 | — | — | WO | disclosed |