Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BHMT | Q93088 | 11/20 | 0.92 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.58 |
| ▸ | NOS2 | P35228 | 2/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | NOS1 | P29475 | 1/20 | 0.53 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1038667 | 1.00 | BHMT (0.92) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL9056803 | 1.00 | BHMT (0.92) | BHMTBHMT2NOS2NOS3NOS1 | |
| Lysine SCHEMBL9746897 | 0.88 | BHMT (0.72) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL6664390 | 0.87 | BHMT (0.71) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL1031686 | 0.86 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL21851894 | 0.86 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL1031684 | 0.86 | BHMT (0.76) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL14125538 | 0.85 | BHMT (0.69) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL14125660 | 0.85 | BHMT (0.69) | BHMTBHMT2NOS2NOS3NOS1 | |
| SCHEMBL14125658 | 0.85 | BHMT (0.69) | BHMTBHMT2NOS2NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4288433-A | THIOETHER AND A XANTHINE DERIVATIVE | L'OREAL (FR) | 1981-09-08 | — | — | US | claimed |
| EP-1879613-B1 | PEPTIDE CONJUGATE COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2011-11-30 | — | — | EP | disclosed |
| CN-101171031-B | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease | MERCK & CO INC | 2011-09-28 | — | — | CN | disclosed |
| US-20110052611-A1 | PEPTIDE CONJUGATE COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE | GARSKY VICTOR M | 2011-03-03 | — | — | US | disclosed |
| EP-2269633-A1 | Peptide conjugate compositions and methods for the prevention and treatment of Alzheimer's disease | Merck Sharp & Dohme Corp. (US) | 2011-01-05 | — | — | EP | disclosed |
| US-7850973-B2 | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease | MERCK SHARP & DOHME CORP. (US) | 2010-12-14 | — | — | US | disclosed |
| EP-0497525-B2 | Pneumococcal polysaccharide conjugate vaccine | MERCK & CO INC (US) | 2010-03-03 | — | — | EP | disclosed |
| US-20090098155-A1 | Peptide conjugate compositions and methods for the prevention and treatment of alzheimer's disease | MERCK SHARP & DOHME CORP. | 2009-04-16 | — | — | US | disclosed |
| US-20090047303-A1 | Method for improving the immunogenicity of plasmodium antigens | MERCK SHARP & DOHME CORP. | 2009-02-19 | — | — | US | disclosed |
| EP-1603590-A4 | INFLUENZA VIRUS VACCINE | MERCK & CO INC (US) | 2008-08-27 | — | — | EP | disclosed |
| EP-0161188-B1 | COVALENTLY-MODIFIED BACTERIAL POLYSACCHARIDES, STABLE COVALENT CONJUGATES OF SUCH POLYSACCHARIDES AND IMMUNOGENIC PROTEINS WITH BIGENERIC SPACERS, AND METHODS OF PREPARING SUCH POLYSACCHARIDES AND CONJUGATES AND OF CONFIRMING COVALENCY | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| EP-0402088-A2 | Conjugate immunogen for aids | MERCK & CO. INC. (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4882317-A | SOLUBILIZATION | MERCK & CO., INC. (US) | 1989-11-21 | — | — | US | disclosed |
| US-4830852-A | COVALENT-MODIFICATION AND HAVING A COUPLING SPACER CONTAINING A THIOETHER; VACCINES; CHEMICAL STABILITY; INFANT PROTECTION | MERCK & CO INC. (US) | 1989-05-16 | — | — | US | disclosed |
| US-4695624-A | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency | MERCK & CO., INC. (US) | 1987-09-22 | — | — | US | disclosed |
| CN-85104164-A | Preparation method of covalent conjugate of bacterial polysaccharide and immunogen protein | — | 1987-02-04 | — | — | CN | disclosed |
| CN-85108890-A | The preparation covalent modification neutral bacterial polysaccharides and with the method that causes the banded stable covalent conjunct agent of immune protein | — | 1986-11-19 | — | — | CN | disclosed |
| EP-0186576-A2 | Covalently-modified neutral bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins, and methods of preparing such polysaccharides and conjugates | MERCK & CO. INC. (US) | 1986-07-02 | — | — | EP | disclosed |
| EP-0161188-A2 | Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency | MERCK & CO. INC. (US) | 1985-11-13 | — | — | EP | disclosed |
| US-4288433-A | THIOETHER AND A XANTHINE DERIVATIVE | L'OREAL (FR) | 1981-09-08 | — | — | US | disclosed |