Sugi Predict

Sugi Predict / Targets / BHMT

BHMT

Betaine--homocysteine S-methyltransferase 1 · Q93088 · BHMT on Sugi Atlas →

8,882 patent compounds predicted against BHMT, 6,017 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL1038667 SCHEMBL1038667 0.92 11/20
SCHEMBL1038668 SCHEMBL1038668 0.92 11/20
SCHEMBL1031684 SCHEMBL1031684 0.76 11/20
SCHEMBL1031686 SCHEMBL1031686 0.76 11/20
SCHEMBL474954 SCHEMBL474954 0.69 11/20
SCHEMBL474955 SCHEMBL474955 0.69 11/20
SCHEMBL474956 SCHEMBL474956 0.69 11/20
SCHEMBL474910 SCHEMBL474910 0.67 11/20
SCHEMBL474911 SCHEMBL474911 0.67 11/20
SCHEMBL60520 SCHEMBL60520 0.66 11/20
SCHEMBL474816 SCHEMBL474816 0.66 11/20
SCHEMBL474818 SCHEMBL474818 0.66 11/20
SCHEMBL474867 SCHEMBL474867 0.66 11/20
SCHEMBL1285565 SCHEMBL1285565 0.66 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL475108) 0.64 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL475109) 0.64 11/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL475111) 0.64 11/20
Ethionine Ethionine (SCHEMBL8966) 0.63 11/20
Ethionine Ethionine (SCHEMBL8967) 0.63 11/20
SCHEMBL81860 SCHEMBL81860 0.62 11/20

Clinical trials — most relevant to BHMT by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Folic Acid and Creatine as Therapeutic Approaches for Lowering Blood Arsenic PHASE4COMPLETED
Study With Heptral in Subjects With Liver Disease Due to Alcohol Consumption PHASE3COMPLETED
Efficacy Study of Folic Acid Supplementation in Adolescent Epileptics PHASE3UNKNOWN
Serine Supplementation for Obese Subjects With Fatty Liver Disease PHASE1/PHASE2COMPLETED
Betaine METABOLISM OF PATIENTS With Homocystinuria PHASE2COMPLETED
Folate Rechallenge PHASE2COMPLETED
Safety and Efficacy of BMS-986504 in Unresectable Malignant Peripheral Nerve Sheath Tumor PHASE1/PHASE2NOT_YET_RECRUITING
Oxidative Stress Markers In Inherited Homocystinuria And The Impact Of Taurine PHASE1/PHASE2COMPLETED
Effect of S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine PHASE1COMPLETED
A Study of the Interaction Between Tumor Susceptibility Gene Glycine N-methyltransferase (GNMT) and Lung Cancer nanUNKNOWN
Role of a Dietary Supplement in Lowering SAH in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels nanCOMPLETED
Efficacy of Essential Phospholipid Versus Betaine HCL/L-Glutamic Acid in MAFLD nanNOT_YET_RECRUITING
Early Nutritional Intervention in Patients With Autism Spectrum Disorders nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation nanCOMPLETED
Treating Oxidative Stress and the Metabolic Pathology of Autism nanCOMPLETED
Proof of Concept Creatine Supplementation for Homocystinuria Study nanACTIVE_NOT_RECRUITING
5-methyltetrahydrofolate Survival and Inflammation in ESRD Patients nanCOMPLETED
Effect of Adding Folic Acid on Lipid Parameters in Population With Dyslipidemias nanUNKNOWN
Effects of Exercise on Metabolic Parameters in Classical Homocystinuria nanCOMPLETED
Harmonized Micronutrient Project nanCOMPLETED
Natural Folate vs. Synthetic Folic Acid in Pregnancy nanCOMPLETED
DNA Methylation and Arsenic-associated Urothelial Carcinoma nanUNKNOWN
Investigation of Methylation of EGFR in the Response of the Cetuximab in Metastatic Colorectal Cancer Patients nanCOMPLETED
S-adenosylmethionine Plus Choline in Treatment of Patients With Alcoholic Liver Disease nanUNKNOWN
Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Pakistan nanWITHDRAWN
Study of Neurological Complication After Radiotherapy for High Grade Glioblastoma nanUNKNOWN
Maternal Methyl-Nutrient Status and Infant Neurodevelopment Study nanRECRUITING
Study of Homocysteine Metabolism in Homocystinuria nanCOMPLETED
Patient and Observer Reported Outcome Measurements in Inborn Errors of Metabolism nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a BHMT binder may also engage these)

ProteinNameSimilarity
Q5RFG2 — 1.000 Q5RFG2 →
O09171 — 1.000 O09171 →
O35490 — 1.000 O35490 →
Q5M8Z0 — 0.997 Q5M8Z0 →
Q5I597 — 0.995 Q5I597 →
Q5XGM3 — 0.995 Q5XGM3 →
Q95332 — 0.982 Q95332 →
BHMT2 S-methylmethionine--homocysteine S-methyltransferase BHMT2 0.982 landscape →
Q5RF32 — 0.982 Q5RF32 →
Q32LQ4 — 0.978 Q32LQ4 →
Q8CHR6 — 0.970 Q8CHR6 →
Q68FT5 — 0.969 Q68FT5 →
Q28943 — 0.967 Q28943 →
Q28007 — 0.966 Q28007 →
Q91WS4 — 0.965 Q91WS4 →
O89000 — 0.965 O89000 →
Q2RAK2 — 0.964 Q2RAK2 →
Q5R895 — 0.964 Q5R895 →
B8BJ39 — 0.963 B8BJ39 →
Q6NYG8 — 0.962 Q6NYG8 →
Q2QZ86 — 0.962 Q2QZ86 →
O80526 — 0.961 O80526 →
Q3T0V9 — 0.960 Q3T0V9 →
Q2QXR8 — 0.960 Q2QXR8 →
DPYD Dihydropyrimidine dehydrogenase [NADP(+)] 0.960 landscape →
ACACA Acetyl-CoA carboxylase 1 0.960 landscape →
Q9HD40 — 0.959 Q9HD40 →
Q80Z29 — 0.959 Q80Z29 →
Q2QNG7 — 0.958 Q2QNG7 →
DERA Deoxyribose-phosphate aldolase 0.958 landscape →