Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 8/20 | 0.51 |
| ▸ | KLK5 | Q9Y337 | 7/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334611 | 1.00 | KLK7 (0.51) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL10387738 | 1.00 | KLK7 (0.51) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL247530 | 0.83 | KLK7 (0.54) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL7331869 | 0.81 | ALDH1A1 (0.43) | KLK7RIPK1KMT2A | |
| SCHEMBL3730644 | 0.81 | NR1H2 (0.45) | KLK7RIPK1KMT2ANR1H2 | |
| SCHEMBL823090 | 0.79 | POLB (0.55) | RIPK1KMT2A | |
| SCHEMBL817748 | 0.79 | POLB (0.55) | RIPK1KMT2A | |
| SCHEMBL29246174 | 0.78 | SMYD2 (0.38) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL29246175 | 0.78 | SMYD2 (0.38) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL30188688 | 0.78 | SMYD2 (0.38) | KLK7KLK5PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4978759-A | REACTING MELDRUM*S ACID WITH PROTECTED AMINO ACID, CYCLIZATION DECYCLIZING, REDUCTION AND DEPROTECTING; STATINE | SANOFI, S.A. AND INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (FR) | 1990-12-18 | — | — | US | disclosed |