Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.57 |
| ▸ | HTR2A | P28223 | 11/20 | 0.57 |
| ▸ | HTR1A | P08908 | 10/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR1E | P28566 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL1039154 | 0.99 | DRD2 (0.56) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| SCHEMBL1037955 | 0.88 | DRD2 (0.63) | DRD2HTR2AHTR1ASLC6A4ADRA1A | |
| SCHEMBL1036129 | 0.86 | DRD2 (0.61) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL1036490 | 0.86 | DRD2 (0.60) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| SCHEMBL5539823 | 0.85 | DRD2 (0.61) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| SCHEMBL1037956 | 0.80 | DRD2 (0.67) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL1038759 | 0.79 | DRD2 (0.66) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| SCHEMBL29433199 | 0.78 | DRD2 (0.75) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL1038256 | 0.76 | DRD2 (0.70) | DRD2HTR2AHTR1AADRB2ADRB1 | |
| Hydrochloric Acid SCHEMBL1040466 | 0.76 | DRD2 (0.69) | DRD2HTR2AHTR1AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1869025-B1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMA CO LTD (JP) | 2011-01-26 | — | — | EP | disclosed |
| EP-1869025-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006112464-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-10-26 | — | — | WO | disclosed |