Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10389394 | 0.88 | POLB (0.52) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389641 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389901 | 0.83 | POLB (0.52) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389913 | 0.82 | BRD4 (0.69) | ALDH1A1POLBKDM4ESMN1; SMN2MAPT | |
| SCHEMBL10389947 | 0.82 | BRD4 (0.65) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389636 | 0.81 | POLB (0.53) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389656 | 0.78 | BRD4 (0.54) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389907 | 0.77 | POLB (0.53) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10391047 | 0.71 | POLB (0.76) | ALDH1A1LMNAPOLBGAAKDM4E | |
| SCHEMBL10389280 | 0.70 | BRD4 (0.74) | ALDH1A1POLBKDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4892873-A | MUSCLE RELAXANTS, ANTIEPILEPTIC, AN XIOLYTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1990-01-09 | — | — | US | disclosed |
| US-4767765-A | ANXIOLYTIC OR ANTIEPILEPTIC AGENTS | AMERICAN CYANAMID COMPANY (US) | 1988-08-30 | — | — | US | disclosed |
| US-4654343-A | USEFUL AS ANXIOLYTIC OR ANTIEPILEPTIC AGENTS AS WELL AS SEDATIVE-HYPNOTIC AND SKELETAL MUSCLE RELAXANT AGENTS | AMERICAN CYANAMID COMPANY (US) | 1987-03-31 | — | — | US | disclosed |