Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 7/20 | 0.50 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.42 |
| ▸ | CHRNG | P07510 | 1/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRND | Q07001 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4944203 | 0.92 | CHRNB2 (0.57) | CHRNB2CHRNA4KMT2ACHRNA3CHRNA7 | |
| SCHEMBL27553087 | 0.85 | CHRNB2 (0.61) | CHRNB2CHRNA4KMT2ACHRNA3CHRNA7 | |
| SCHEMBL31742565 | 0.85 | CHRNB2 (0.65) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL10390507 | 0.80 | KCNA3 (0.59) | NPC1MAPTSMN1; SMN2 | |
| SCHEMBL1428297 | 0.80 | CHRNB2 (0.62) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL10802704 | 0.79 | KCNA3 (0.61) | NPC1MAPTSMN1; SMN2 | |
| SCHEMBL23596366 | 0.78 | CHRNB2 (0.60) | CHRNB2CHRNA4KMT2ANPC1LMNA | |
| SCHEMBL20930335 | 0.78 | CHRNB2 (0.56) | CHRNB2CHRNA4CHRNA3CHRNA7CHRNA1 | |
| SCHEMBL29469519 | 0.78 | CHRNB2 (0.56) | CHRNB2CHRNA4KMT2ACHRNA3CHRNB4 | |
| SCHEMBL12568183 | 0.78 | CHRNB2 (0.56) | CHRNB2CHRNA4KMT2ACHRNA3CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4937268-A | TREATMENT OF ASTHMA, CHRONIC BRONCHITIS | GLAXO GROUP LIMITED (GB) | 1990-06-26 | — | — | US | disclosed |
| EP-0286242-A2 | Ethanolamine derivates, processes for their preparation and pharmaceutical compositions containing them | GLAXO GROUP LIMITED (GB) | 1988-10-12 | — | — | EP | disclosed |