Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10395875 | 0.89 | MAPT (0.54) | MAPTPOLB | |
| SCHEMBL10396987 | 0.89 | MAPT (0.47) | MAPTPOLB | |
| SCHEMBL16760632 | 0.83 | POLB (0.59) | RAB9AKMT2AMAPTPOLB | |
| SCHEMBL10728803 | 0.81 | BCL2L1 (0.51) | MEN1RAB9AKMT2AMAPTSIRT1 | |
| SCHEMBL10627982 | 0.80 | SRD5A2 (0.56) | MEN1RAB9AKMT2AMAPTSIRT1 | |
| SCHEMBL10396589 | 0.80 | NR4A1 (0.53) | MEN1RAB9AKMT2AMAPTTDP1 | |
| SCHEMBL7273972 | 0.78 | SRD5A2 (0.52) | MEN1KMT2AMAPTSIRT1 | |
| SCHEMBL219922 | 0.77 | KDM4E (0.66) | MEN1KMT2AMAPTTDP1NR4A1 | |
| SCHEMBL29917566 | 0.77 | KDM4E (0.66) | MEN1KMT2AMAPTTDP1NR4A1 | |
| SCHEMBL19646057 | 0.77 | KDM4E (0.46) | RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4898874-A | Acetic acid derivatives of 3-aryl-2,1-benzisoxazole and esters and amides thereof | A. H. ROBINS COMPANY, INC. (US) | 1990-02-06 | — | — | US | disclosed |
| EP-0260924-A1 | Antiinflammatory derivatives of 3-aryl-2,1-benzisoxazole | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-03-23 | — | — | EP | disclosed |