SCHEMBL10396993

SCHEMBL10396993

CC1(C)CC(NC(=O)C(=O)NN2C(=O)c3c(Br)c(Br)c(Br)c(Br)c3C2=O)CC(C)(C)N1

nearest known ligand 0.45

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.43
ALDH1A1 P00352 3/20 0.42
TP53 P04637 2/20 0.42
GLA P06280 2/20 0.42
HSD17B10 Q99714 2/20 0.42
KDM4E B2RXH2 1/20 0.42
MAPK1 P28482 1/20 0.42
POLB P06746 3/20 0.40
RECQL P46063 2/20 0.39
MEN1 O00255 1/20 0.39
MAPT P10636 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
EZH2 Q15910 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.37
ATM Q13315 1/20 0.37
HTT P42858 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10397603 0.88 ALDH1A1 (0.43) GAAALDH1A1TP53GLAHSD17B10
SCHEMBL10396696 0.86 GAA (0.42) GAAALDH1A1TP53MAPK1POLB
SCHEMBL10396618 0.84 HDAC4 (0.32) GAAKDM4E
SCHEMBL10397614 0.82
SCHEMBL9544681 0.81 GAA (0.46) GAAALDH1A1TP53GLAHSD17B10
SCHEMBL10396686 0.79 ALDH1A1 (0.39) GAAALDH1A1TP53GLAHSD17B10
SCHEMBL10562866 0.76 GAA (0.43) GAAALDH1A1TP53HSD17B10POLB
SCHEMBL10398091 0.76 GAA (0.41) GAAALDH1A1TP53GLAHSD17B10
SCHEMBL3295977 0.76 RECQL (0.57) GAAALDH1A1GLAHSD17B10KDM4E
SCHEMBL10560570 0.73 GAA (0.43) GAAALDH1A1TP53HSD17B10POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4978699-A Reaction product of hindered amine with primary amine or reactive hydrazide group and halogenated cyclic anhydride; for extrusion with polymers ATOCHEM NORTH AMERICA, INC. (US) 1990-12-18 US claimed
EP-0366057-A2 Light stabilizing flame retardants ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) 1990-05-02 EP claimed
US-4978699-A Reaction product of hindered amine with primary amine or reactive hydrazide group and halogenated cyclic anhydride; for extrusion with polymers ATOCHEM NORTH AMERICA, INC. (US) 1990-12-18 US disclosed
EP-0366057-A2 Light stabilizing flame retardants ATOCHEM NORTH AMERICA, INC. (a Pennsylvania corp.) (US) 1990-05-02 EP disclosed