Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | GNRHR | P30968 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391819 | 1.00 | HDAC1 (0.44) | HDAC1HDAC8GNRHRGAAPPARG | |
| SCHEMBL1043372 | 0.87 | GAA (0.48) | HDAC1GNRHRGAAPPARGBRD4 | |
| SCHEMBL12391808 | 0.87 | GAA (0.48) | HDAC1GNRHRGAAPPARGBRD4 | |
| SCHEMBL12391820 | 0.86 | GNRHR (0.42) | HDAC1HDAC8GNRHRGAAPPARG | |
| SCHEMBL1043674 | 0.86 | GNRHR (0.42) | HDAC1HDAC8GNRHRGAAPPARG | |
| SCHEMBL3235885 | 0.86 | GAA (0.53) | HDAC1GAAFPR1ALOX5APUSP2 | |
| SCHEMBL3493003 | 0.86 | GAA (0.53) | HDAC1GAAFPR1ALOX5APUSP2 | |
| SCHEMBL12391823 | 0.84 | USP2 (0.43) | HDAC1GNRHRGAAPPARGBRD4 | |
| SCHEMBL1043987 | 0.84 | USP2 (0.43) | HDAC1GNRHRGAAPPARGBRD4 | |
| SCHEMBL1039663 | 0.82 | TSHR (0.42) | HDAC1GNRHRGAAPPARGBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008335-B2 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-2275412-A1 | Indole and benzimidazole derivatives | Novartis Vaccines and Diagnostics, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | CHIRON CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1807399-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049835-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060084687-A1 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084687-A1 | Indole and benzimidazole derivatives | IDO1, IDO2, AADAC | HDAC1 121/4885HDAC8 171/4885GNRHR 2526/4885 |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | IDO1, IDO2, AADAC | HDAC1 121/4885HDAC8 171/4885GNRHR 2526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.