Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | GNRHR | P30968 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | FPR1 | P21462 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12391808 | 1.00 | GAA (0.48) | GAABRD4TSHRTRPC5GNRHR | |
| SCHEMBL12391820 | 0.90 | GNRHR (0.42) | GAABRD4GNRHRPPARGFPR1 | |
| SCHEMBL1043674 | 0.90 | GNRHR (0.42) | GAABRD4GNRHRPPARGFPR1 | |
| SCHEMBL3235885 | 0.89 | GAA (0.53) | GAATSHRMAPTFPR1ALOX5AP | |
| SCHEMBL3493003 | 0.89 | GAA (0.53) | GAATSHRMAPTFPR1ALOX5AP | |
| SCHEMBL13941142 | 0.88 | TSHR (0.60) | GAATSHRMAPT | |
| SCHEMBL1039715 | 0.87 | HDAC1 (0.44) | GAABRD4TSHRGNRHRPPARG | |
| SCHEMBL12391819 | 0.87 | HDAC1 (0.44) | GAABRD4TSHRGNRHRPPARG | |
| SCHEMBL1043987 | 0.87 | USP2 (0.43) | GAABRD4TSHRGNRHRPPARG | |
| SCHEMBL12391823 | 0.87 | USP2 (0.43) | GAABRD4TSHRGNRHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008335-B2 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2011-08-30 | — | — | US | disclosed |
| EP-2275412-A1 | Indole and benzimidazole derivatives | Novartis Vaccines and Diagnostics, Inc. (US) | 2011-01-19 | — | — | EP | disclosed |
| US-7662581-B1 | Eg5 co-crystals | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| US-7608723-B2 | N-(3-aminopropyl)-N-[(1R)-1-(1-benzyl-1H-benzimidazol-2-yl)-2-methylpropyl]-4-chlorobenzamide;kinesin spindle protein modulators; anticarcinogenic agents; in vivo stability, bio-availability; diagnosis/medical/;antitumor agents hyperplasia; restinosis; antiinflammatory agents; cardiac hypertrophy | NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) | 2009-10-27 | — | — | US | disclosed |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | CHIRON CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| EP-1807399-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | Novartis Vaccines and Diagnostics, Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049835-A2 | INDOLE AND BENZIMIDAZOLE DERIVATIVES | NOVARTIS VACCINES AND DIAGNOSTICS INC. (US) | 2006-05-11 | — | — | WO | disclosed |
| US-20060084687-A1 | Indole and benzimidazole derivatives | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2006-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084687-A1 | Indole and benzimidazole derivatives | IDO1, IDO2, AADAC | GAA 1193/4885BRD4 97/4885TSHR 2311/4885 |
| US-20080317744-A1 | Indole and Benzimidazole Derivatives | IDO1, IDO2, AADAC | GAA 1193/4885BRD4 97/4885TSHR 2311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.