SCHEMBL10398482

SCHEMBL10398482

C=CC(=O)OC(C)C(O)CCCC

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 4/20 0.49
HPGD P15428 1/20 0.46
ABCB1 P08183 1/20 0.40
THRB P10828 3/20 0.36
CTSK P43235 4/20 0.36
SPHK1 Q9NYA1 1/20 0.35
MAPT P10636 2/20 0.34
LMNA P02545 2/20 0.33
THRA P10827 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
ACHE P22303 1/20 0.33
BACE1 P56817 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10356373 0.87 TSHR (0.56) TSHRHPGDABCB1THRBCTSK
SCHEMBL29207095 0.85 TSHR (0.47) TSHRHPGDABCB1THRBCTSK
SCHEMBL23494192 0.84 TSHR (0.50) TSHRHPGDTHRBCTSKLMNA
SCHEMBL9007754 0.83 TSHR (0.49) TSHRHPGDTHRBCTSKLMNA
SCHEMBL2424095 0.82 TSHR (0.44) TSHRHPGDTHRBALDH1A1CYP3A4
SCHEMBL7620025 0.81 TSHR (0.51) TSHRHPGDTHRBCTSKLMNA
SCHEMBL5027328 0.81 TSHR (0.50) TSHRHPGDABCB1THRBCTSK
SCHEMBL185499 0.80 TSHR (0.53) TSHRHPGDTHRBCTSKLMNA
SCHEMBL1123116 0.80 TSHR (0.53) TSHRHPGDTHRBCTSKTHRA
SCHEMBL15820924 0.80 TSHR (0.46) TSHRHPGDTHRBCTSKMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4952626-A WEATHERPROOF PROTECTIVE COATINGS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
US-4888399-A Polyester graft copolymers, flexible coating compositions comprising same and branched polyester macromers for preparing same II E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-12-19 US disclosed
US-4873285-A HAVING EXCELLENT ADHESION TO PLASTICS AND METALS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-10-10 US disclosed
US-4873298-A THERMOSETTING COATINGS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-10-10 US disclosed
US-4870140-A Polyester graft copolymers, flexible coating compositions comprising same and branched polyester macromers for preparing same II E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-09-26 US disclosed
EP-0148581-B1 HIGH SOLID COATINGS EXXON RESEARCH AND ENGINEERING COMPANY (US) 1989-03-08 EP disclosed
US-4810759-A AUTOMOBILES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-03-07 US disclosed
US-4804732-A HYDROXY FUNCTIONAL POLYSILOXANE, MELAMINE CROSSLINKING AGENT E. I. DU PONT DE NEMOURS AND COMPANY (US) 1989-02-14 US disclosed
EP-0284679-A1 Polysiloxane graft copolymers, flexible coating compositions comprising same and branched polysiloxane macromers for preparing same E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-10-05 EP disclosed
US-4766185-A Polysiloxane graft copolymers, flexible coating compositions comprising same and branched polysiloxane macromers for preparing same - II E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-08-23 US disclosed
US-4739006-A BLEND CONTAINING ACRYLIC ESTERS AND HYDROXY SUBSTITUTED ACRYLIC ESTERS EXXON RESEARCH & ENGINEERING CO. (US) 1988-04-19 US disclosed
EP-0231666-A2 Polyester graft copolymers and flexible coating compositions comprising same E.I. DU PONT DE NEMOURS AND COMPANY (US) 1987-08-12 EP disclosed
US-4673718-A ADDITION POLYMER GRAFT THROUGH POLYSILOXANE WHICH IS HYDROXY-FUNCTIONAL AND DOUBLE BOND-BEARING E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-06-16 US disclosed
US-4638031-A ELECTROSTATIC SPRAYING, POLYMERIZING HYDROXYALKYL AND ALKYL (METH) ACRYLATES, ESTER SOLVENT, FREE RADICAL CATALYST EXXON RESEARCH & ENGINEERING CO. (US) 1987-01-20 US disclosed
EP-0099647-B1 SUPERIOR SOLVENT BLENDS FOR SYNTHESIS OF ACRYLIC RESINS FOR HIGH SOLIDS COATINGS EXXON RESEARCH AND ENGINEERING COMPANY (US) 1986-09-10 EP disclosed
US-4593080-A Containing hydroxy-substituted alkyl (meth)acrylate EXXON RESEARCH & ENGINEERING CO. (US) 1986-06-03 US disclosed
US-4532294-A Contacting mixture of hydroxyalkyl acrylate, other acrylates in presence of free radical initiator, liquid ester solvent EXXON RESEARCH & ENGINEERING CO. (US) 1985-07-30 US disclosed
EP-0148581-A1 High solid coatings EXXON RESEARCH AND ENGINEERING COMPANY (US) 1985-07-17 EP disclosed
US-4501868-A METHYLISOBUTYL KETONE AND AN ALKYL-SUBSTITUTED BENZENE EXXON RESEARCH & ENGINEERING CO. (US) 1985-02-26 US disclosed
EP-0099647-A2 Superior solvent blends for synthesis of acrylic resins for high solids coatings EXXON RESEARCH AND ENGINEERING COMPANY (US) 1984-02-01 EP disclosed