SCHEMBL10399112

SCHEMBL10399112

COc1ccccc1C(=C/C=C/C(=O)O)c1ccccc1OC

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 1/20 0.50
PTAFR P25105 1/20 0.48
LMNA P02545 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
GPR52 Q9Y2T5 1/20 0.47
CA12 O43570 1/20 0.47
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CA9 Q16790 1/20 0.47
NPC1 O15118 3/20 0.46
RAB9A P51151 2/20 0.46
NFE2L2 Q16236 2/20 0.46
CTSD P07339 1/20 0.46
HTT P42858 1/20 0.46
TFEB P19484 1/20 0.46
KDM4E B2RXH2 2/20 0.46
GAA P10253 1/20 0.46
AR P10275 1/20 0.46
MAOB P27338 1/20 0.46
BCHE P06276 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10399114 1.00 ABCG2 (0.50) ABCG2PTAFRLMNASMN1; SMN2GPR52
SCHEMBL10399176 0.87 MAOB (0.51) ABCG2LMNASMN1; SMN2CA1CA2
SCHEMBL10398891 0.87 MAOB (0.51) ABCG2LMNASMN1; SMN2CA1CA2
SCHEMBL10398890 0.87 MAOB (0.51) ABCG2LMNASMN1; SMN2CA1CA2
SCHEMBL10398967 0.86 PTAFR (0.50) ABCG2PTAFRSMN1; SMN2NPC1RAB9A
SCHEMBL10398965 0.86 PTAFR (0.50) ABCG2PTAFRSMN1; SMN2NPC1RAB9A
Bicarbonate SCHEMBL9518930 0.84 CA12 (0.47) ABCG2PTAFRLMNASMN1; SMN2GPR52
SCHEMBL3432968 0.83 ABCG2 (0.47) ABCG2PTAFRGPR52CA12CA1
SCHEMBL4094783 0.83 CYP1A1 (0.44) LMNASMN1; SMN2NPC1RAB9AKDM4E
SCHEMBL4094791 0.83 CYP1A1 (0.44) LMNASMN1; SMN2NPC1RAB9AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4975438-A ANTICOAGULANT HOFFMANN-LA ROCHE INC. (US) 1990-12-04 US disclosed
US-4788206-A CARDIOVASCULAR DISORDERS, PLATELETS HOFFMANN-LA ROCHE INC. (US) 1988-11-29 US disclosed