Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399182 | 1.00 | LMNA (0.41) | LMNATSHRKCNK3KCNK9GAA | |
| SCHEMBL10397809 | 0.82 | NPC1 (0.46) | LMNATSHRGAAMAPTMDM2 | |
| SCHEMBL10396464 | 0.82 | NPC1 (0.46) | LMNATSHRGAAMAPTMDM2 | |
| SCHEMBL10397808 | 0.82 | NPC1 (0.46) | LMNATSHRGAAMAPTMDM2 | |
| SCHEMBL10398922 | 0.79 | LMNA (0.47) | LMNAKCNK3KCNK9GAAMAOB | |
| SCHEMBL10398920 | 0.79 | LMNA (0.47) | LMNAKCNK3KCNK9GAAMAOB | |
| SCHEMBL3938554 | 0.77 | MAPT (0.45) | LMNATSHRGAAMAPTMAOB | |
| SCHEMBL3938552 | 0.77 | MAPT (0.45) | LMNATSHRGAAMAPTMAOB | |
| SCHEMBL5692921 | 0.76 | MAPT (0.55) | LMNAMAPTMDM2KDM4EALDH1A1 | |
| SCHEMBL5692918 | 0.76 | MAPT (0.55) | LMNAMAPTMDM2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4975438-A | ANTICOAGULANT | HOFFMANN-LA ROCHE INC. (US) | 1990-12-04 | — | — | US | disclosed |
| US-4788206-A | CARDIOVASCULAR DISORDERS, PLATELETS | HOFFMANN-LA ROCHE INC. (US) | 1988-11-29 | — | — | US | disclosed |