SCHEMBL10399574

SCHEMBL10399574

Nc1cnc(-c2ccccc2)c(N)n1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK1A1 P48729 1/20 0.52
CLK4 Q9HAZ1 1/20 0.52
ADORA2A P29274 6/20 0.50
ALDH1A1 P00352 3/20 0.45
KDM4E B2RXH2 2/20 0.45
LMNA P02545 2/20 0.45
GLA P06280 2/20 0.45
HPGD P15428 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
CYP1A2 P05177 2/20 0.44
CYP2D6 P10635 2/20 0.44
JAK2 O60674 1/20 0.44
GMNN O75496 1/20 0.44
TP53 P04637 1/20 0.44
CTSG P08311 1/20 0.44
CYP3A4 P08684 1/20 0.44
GAA P10253 1/20 0.44
CYP2C9 P11712 1/20 0.44
PKM P14618 1/20 0.44
TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2031287 0.85 ADORA2A (0.64) CSNK1A1CLK4ADORA2AALDH1A1KDM4E
SCHEMBL29678556 0.85 ADORA2A (0.64) CSNK1A1CLK4ADORA2AALDH1A1KDM4E
SCHEMBL20600732 0.80 ADORA2A (0.55) CSNK1A1CLK4ADORA2AALDH1A1KDM4E
SCHEMBL10653381 0.80 ADORA2A (0.48) CSNK1A1CLK4ADORA2AALDH1A1KDM4E
SCHEMBL977342 0.80 DHFR (0.53) ADORA2AALDH1A1KDM4ESMN1; SMN2CYP1A2
SCHEMBL11369023 0.77 ADORA2A (0.49) ADORA2AALDH1A1KDM4ELMNAGLA
SCHEMBL20658415 0.76 ADORA2A (0.48) CSNK1A1CLK4ADORA2AALDH1A1KDM4E
SCHEMBL20658596 0.76 ADORA2A (0.67) ADORA2AADORA1CKS1BSKP1SKP2
SCHEMBL20658466 0.76 ADORA2A (0.58) ADORA2AALDH1A1KDM4ELMNAGLA
SCHEMBL6722240 0.76 KMT2A (0.55) ADORA2AALDH1A1KDM4ELMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4931487-A Chain extenders for polyurethanes DOW CHEMICAL COMPANY 1990-06-05 US disclosed