DHFR

Dihydrofolate reductase · P00374 · DHFR on Sugi Atlas →

83,837 patent compounds predicted against DHFR, 46,193 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Pralatrexate (SCHEMBL21633)	1.00	14/20
SCHEMBL13971	0.63	14/20
Edatrexate (SCHEMBL4676)	1.00	13/20
SCHEMBL14314	1.00	13/20
Ch-1504 (SCHEMBL7281)	0.65	13/20
SCHEMBL136836	0.49	13/20
SCHEMBL221621	0.71	11/20
Denopterin (SCHEMBL9294)	0.62	11/20
Trimetrexate (SCHEMBL3635)	0.70	10/20
Aminopterin (SCHEMBL74531)	0.64	10/20
Aminopterin (SCHEMBL74532)	0.61	10/20
Trimetrexate (SCHEMBL3983)	1.00	9/20
Aminopterin (SCHEMBL8887)	0.76	9/20
Folic Acid (SCHEMBL3878)	0.67	9/20
SCHEMBL95414	0.64	9/20
Pteropterin (SCHEMBL8991)	0.66	8/20
Pteropterin (SCHEMBL8992)	0.66	8/20
SCHEMBL265154	0.59	8/20
Trimetrexate (SCHEMBL166271)	0.58	8/20
SCHEMBL142710	0.51	8/20

Clinical trials — most relevant to DHFR by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Topical Methotrexate Microemulsion in the Treatment of Plaque Psoriasis	PHASE4	UNKNOWN
Effectiveness of Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Type Two Hybrid Implementation Study	PHASE4	UNKNOWN
Efficacy of Antifolates Against Malaria in HIV-infected Pregnant Women and the Emergence of Induced Resistance in Plasmodium Falciparum	PHASE3	COMPLETED
A Study of PTC923 in Participants With Phenylketonuria	PHASE3	COMPLETED
Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DM	PHASE3	COMPLETED
Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine	PHASE2/PHASE3	UNKNOWN
A Study to Assess CH1504 in Patients With Active Rheumatoid Arthritis	PHASE2	COMPLETED
Liver Resection and Floxuridine Plus Fluorouracil and Leucovorin in Treating Patients With Liver Metastases From Colorectal Cancer	PHASE2	COMPLETED
Pemetrexed in Combination With Erlotinib as a Salvage Treatment in Patients With Metastatic Biliary Tract Cancer (BTC) Who Failed Gemcitabine Containing Chemotherapy: A Phase II Single Arm Prospective Study	PHASE2	UNKNOWN
Pemetrexed Disodium With or Without Sorafenib as Second-Line Therapy in Treating Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer	PHASE2	COMPLETED
Bortezomib and Pemetrexed Disodium in Treating Patients With Advanced Non-Small Cell Lung Cancer or Other Solid Tumors	PHASE1/PHASE2	COMPLETED
Metronomic Chemotherapy With Tegafur/Uracil for Head and Neck Squamous Cell Carcinoma	PHASE2	UNKNOWN
Pyrimethamine for Intermediate/High-risk Myelodysplastic Syndromes (MDS)	PHASE1	WITHDRAWN
Pemetrexed Disodium in Treating Young Patients With Recurrent Solid Tumors	PHASE1	COMPLETED
Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study	EARLY_PHASE1	UNKNOWN
DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization	nan	COMPLETED
Thymidylate Synthase Polymorphisms as a Predictor of Toxicity to 5-Fluorouracil Based Chemotherapy in Stage III Colon Cancer	nan	UNKNOWN
C677T and A1298C MTHFR Polymorphisms and Fluoropyrimidine Effectiveness in Metastatic Colon Cancer	nan	UNKNOWN
SPK Study in Afghanistan	nan	COMPLETED
Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii	nan	ACTIVE_NOT_RECRUITING
Tumor Response to Pemetrexed Disodium in Patients With Stage III or Stage IV Non-Small Cell Lung Cancer Enrolled in Clinical Trial MCCRC-RC0524	nan	COMPLETED
Ticopa Serum Analysis: an Analysis of Blood Samples From the TICOPA Study	nan	UNKNOWN
Clinical Antenatal Randomised Study to CharactErise Key Roles of TetrahydroFOLate in HyperTensive Pregnancies	nan	RECRUITING
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial	nan	NOT_YET_RECRUITING
Predicting Response to Capecitabine in Women With Metastatic Breast Cancer	nan	COMPLETED
Mechanistic Studies of Teriflunomide in RRMS	nan	COMPLETED
TIPTOP Sulfadoxine-pyrimethamine (SP) Drug Resistance Study	nan	COMPLETED
EnBrace HR for Depression Treatment and Prevention in Women Trying to Conceive and Early Pregnancy	nan	COMPLETED
Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study	nan	COMPLETED
PK/PD Investigation of Calciumfolinat in Blood, Tumor and Adjacent Mucosa in Patient With Colon Cancer	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a DHFR binder may also engage these)

Protein	Name	Similarity
Q86XF0	—	0.993	Q86XF0 →
P04753	—	0.993	P04753 →
P00375	—	0.988	P00375 →
Q920D2	—	0.986	Q920D2 →
P00377	—	0.986	P00377 →
P00376	—	0.984	P00376 →
P00378	—	0.981	P00378 →
P09503	—	0.976	P09503 →
P27421	—	0.937	P27421 →
Q9D020	—	0.935	Q9D020 →
Q28DS0	—	0.934	Q28DS0 →
Q5R962	—	0.933	Q5R962 →
Q05B63	—	0.933	Q05B63 →
B9N1F9	—	0.932	B9N1F9 →
Q9CWH5	—	0.932	Q9CWH5 →
Q5R8R4	—	0.931	Q5R8R4 →
Q5R514	—	0.931	Q5R514 →
E0CSI1	—	0.931	E0CSI1 →
Q2R483	—	0.930	Q2R483 →
Q8JGT5	—	0.930	Q8JGT5 →
Q8R4N0	—	0.930	Q8R4N0 →
Q9FN41	—	0.930	Q9FN41 →
Q5ZID6	—	0.929	Q5ZID6 →
B4G0F3	—	0.929	B4G0F3 →
Q5RFI8	—	0.929	Q5RFI8 →
Q7Z4G4	—	0.928	Q7Z4G4 →
B8BKI7	—	0.928	B8BKI7 →
Q6AY30	—	0.928	Q6AY30 →
AASDHPPT	L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.928	landscape →
P29411	—	0.928	P29411 →