Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 9/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | SNCA | P37840 | 3/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399645 | 1.00 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL10399797 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL10399799 | 0.87 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL10555231 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL10555230 | 0.87 | ALDH1A1 (0.53) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL10398754 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL10398635 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL10398636 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HPGD | |
| SCHEMBL10398755 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1SMN1; SMN2HSD17B10 | |
| SCHEMBL10399669 | 0.84 | ALDH1A1 (0.49) | ALDH1A1KMT2AMEN1HSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977178-A | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4879391-A | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents | PFIZER INC. (US) | 1989-11-07 | — | — | US | disclosed |
| US-4861880-A | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4476307-A | Heteroylidene indolone compounds | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0104860-A1 | 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1984-04-04 | — | — | EP | disclosed |