Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 2/20 | 0.64 |
| ▸ | IDO1 | P14902 | 2/20 | 0.64 |
| ▸ | TDO2 | P48775 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.60 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.57 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.57 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.57 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.57 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.57 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399723 | 1.00 | TGM2 (0.64) | TGM2IDO1TDO2SMN1; SMN2LRRK2 | |
| SCHEMBL10398764 | 0.87 | SMN1; SMN2 (0.61) | TGM2IDO1TDO2SMN1; SMN2LRRK2 | |
| SCHEMBL10398762 | 0.87 | SMN1; SMN2 (0.61) | TGM2IDO1TDO2SMN1; SMN2LRRK2 | |
| SCHEMBL14446379 | 0.83 | TGM2 (0.68) | TGM2IDO1TDO2LRRK2PSEN1 | |
| SCHEMBL12841407 | 0.81 | LRRK2 (0.65) | TGM2IDO1TDO2LRRK2PSEN1 | |
| SCHEMBL1534167 | 0.81 | LRRK2 (0.65) | TGM2IDO1TDO2LRRK2PSEN1 | |
| SCHEMBL1534169 | 0.81 | LRRK2 (0.65) | TGM2IDO1TDO2LRRK2PSEN1 | |
| SCHEMBL11027773 | 0.81 | SMN1; SMN2 (0.61) | TGM2SMN1; SMN2PDGFRBRPS6KA3 | |
| SCHEMBL11027779 | 0.81 | SMN1; SMN2 (0.61) | TGM2SMN1; SMN2PDGFRBRPS6KA3 | |
| SCHEMBL4858381 | 0.80 | TGM2 (0.72) | TGM2IDO1TDO2LRRK2PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977178-A | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4879391-A | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents | PFIZER INC. (US) | 1989-11-07 | — | — | US | disclosed |
| US-4861880-A | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4476307-A | Heteroylidene indolone compounds | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0104860-A1 | 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1984-04-04 | — | — | EP | disclosed |