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TGM2

Protein-glutamine gamma-glutamyltransferase · P21980 · TGM2 on Sugi Atlas →

71,702 patent compounds predicted against TGM2, 42,787 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL168530 SCHEMBL168530 0.64 15/20
SCHEMBL177827 SCHEMBL177827 0.41 13/20
SCHEMBL347622 SCHEMBL347622 0.40 13/20
SCHEMBL136355 SCHEMBL136355 0.43 12/20
SCHEMBL81209 SCHEMBL81209 1.00 11/20
SCHEMBL309691 SCHEMBL309691 0.49 11/20
SCHEMBL25112 SCHEMBL25112 0.42 11/20
SCHEMBL261812 SCHEMBL261812 0.85 10/20
SCHEMBL133445 SCHEMBL133445 0.68 10/20
SCHEMBL309243 SCHEMBL309243 0.64 10/20
SCHEMBL308426 SCHEMBL308426 0.53 10/20
SCHEMBL16899 SCHEMBL16899 0.47 10/20
SCHEMBL287192 SCHEMBL287192 0.44 10/20
SCHEMBL287193 SCHEMBL287193 0.44 10/20
SCHEMBL177994 SCHEMBL177994 0.42 10/20
SCHEMBL39036 SCHEMBL39036 0.72 9/20
SCHEMBL282066 SCHEMBL282066 0.54 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL333888) 0.53 9/20
Hydrochloric Acid Hydrochloric Acid (SCHEMBL333889) 0.53 9/20
SCHEMBL236887 SCHEMBL236887 0.52 9/20

Clinical trials — most relevant to TGM2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Study to Evaluate the Diagnostic Performance of GEH300079 (68Ga) Injection PET/CT for Detection of PC in Patients With Colorectal, Gastric, Ovarian, or Pancreatic Cancers (PERISCOPE) PHASE2/PHASE3RECRUITING
SGM-101 in Locally Advanced and Recurrent Rectal Cancer PHASE2/PHASE3UNKNOWN
Effectiveness of Inactive Vitamin D Supplementation in Non-Alcoholic Fatty Liver Disease Patients PHASE3UNKNOWN
SGM-101 in Colorectal Brain Metastases. PHASE2UNKNOWN
Triplezumab Combined With CAPEOX Regimen in Neoadjuvant Therapy for Locally Advanced Colon Cancer PHASE2UNKNOWN
A Phase II Open-label Single-arm Study to Evaluate the Efficacy and Safety of ADSCs in Subjects With Liver Cirrhosis PHASE2UNKNOWN
SGM-101 in Colorectal Lung Metastases PHASE2UNKNOWN
Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic PHASE2ACTIVE_NOT_RECRUITING
Gemcitabine Hydrochloride and Cisplatin or High-Dose Methotrexate, Vinblastine, Doxorubicin Hydrochloride, and Cisplatin in Treating Patients With Urothelial Cancer PHASE2WITHDRAWN
Humanized Monoclonal Antibody 3F8 (Hu3F8) With Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) in the Treatment of Recurrent Osteosarcoma PHASE2ACTIVE_NOT_RECRUITING
A Study to Assess the Safety, Tolerability, and Antileukemic Activity of Debio 1562M in Participants With Acute Myeloid Leukemia (AML) PHASE1/PHASE2RECRUITING
Paclitaxel, Cisplatin, and Filgrastim Combined With Radiation Therapy in Treating Patients With Locally Recurrent Head and Neck Cancer PHASE2COMPLETED
GRN1005 for Brain Metastases From Breast or Lung Cancer PHASE2WITHDRAWN
A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease PHASE1COMPLETED
A Study of MCARH109 and MCARH125 in People With Multiple Myeloma PHASE1ACTIVE_NOT_RECRUITING
Tolerability of Enteral NAC in Infants PHASE1NOT_YET_RECRUITING
BTK Inhibitor DTRMWXHS-12 in Mantle Cell Lymphoma PHASE1COMPLETED
A Randomized, Double-blind, Study to Explore the Effect of GED-0301 in Subjects With Active Crohn's Disease PHASE1COMPLETED
Evaluate TCRT-ESO-A2 Autologous T Cells Expressing TCR Specific for NY-ESO-1 in Subjects With Advanced Solid Tumors PHASE1WITHDRAWN
A Study To Investigate The Absorption, Distribution, Metabolism, And Excretion Of [14c]PF-06463922 In Healthy Male Volunteers PHASE1COMPLETED
Phase 1 Clinical Study of GenSci155 Injection in Healthy Adults PHASE1NOT_YET_RECRUITING
Clinical Study on Exploring High Risk Factors Inducing the Progress of Diabetes nanUNKNOWN
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule nanUNKNOWN
Impact of Body Composition on Bisoprolol and Ramipril Pharmacokinetics in Patients With Chronic Heart Failure nanUNKNOWN
Mediterranean Lifestyle Intervention in Patients With Non-alcoholic Fatty Liver Disease nanCOMPLETED
A Decentralized Home-Based Study To Investigate Novel Objective Biomarker Of Gluten-Mediated Symptoms In Celiac Disease Participants (CeDar ROSE Study) nanCOMPLETED
Markers of Liver Apoptosis After Anesthesia With Sevoflurane or Propofol nanCOMPLETED
Relation Between Carotid Atheroscerosis With DM &Fatty Liver nanUNKNOWN
Monitoring and Managing Glucose Levels in People With Pancreatic Cancer nanRECRUITING
Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a TGM2 binder may also engage these)

ProteinNameSimilarity
P51176 — 1.000 P51176 →
P08587 — 1.000 P08587 →
P21981 — 1.000 P21981 →
Q01841 — 1.000 Q01841 →
Q9WVJ6 — 1.000 Q9WVJ6 →
P52181 — 0.994 P52181 →
O08619 — 0.992 O08619 →
P49222 — 0.992 P49222 →
A6QP57 — 0.991 A6QP57 →
Q08189 — 0.990 Q08189 →
Q8BZH1 — 0.989 Q8BZH1 →
F13A1 Coagulation factor XIII A chain 0.989 landscape →
P49221 — 0.988 P49221 →
Q9D7I9 — 0.988 Q9D7I9 →
O46510 — 0.988 O46510 →
D4A5U3 — 0.988 D4A5U3 →
P23606 — 0.988 P23606 →
Q8BH61 — 0.988 Q8BH61 →
P22758 — 0.987 P22758 →
Q96PF1 — 0.987 Q96PF1 →
TGM1 Protein-glutamine gamma-glutamyltransferase K 0.987 landscape →
Q05187 — 0.986 Q05187 →
P16452 — 0.985 P16452 →
TGM3 Protein-glutamine gamma-glutamyltransferase E 0.985 landscape →
Q9JLF6 — 0.985 Q9JLF6 →
O43548 — 0.985 O43548 →
TGM6 Protein-glutamine gamma-glutamyltransferase 6 0.984 landscape →
Q9GLK0 — 0.984 Q9GLK0 →
P52183 — 0.983 P52183 →
Q99041 — 0.982 Q99041 →