Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN2A | Q99250 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 14/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 7/20 | 0.47 |
| ▸ | SNCA | P37840 | 7/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10399763 | 1.00 | SCN2A (0.56) | SCN2AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10399748 | 0.87 | SCN2A (0.59) | SCN2AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10399750 | 0.87 | SCN2A (0.59) | SCN2AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10399734 | 0.84 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10399731 | 0.84 | MAPT (0.63) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10398712 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10398711 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10398747 | 0.82 | ALDH1A1 (0.52) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10555424 | 0.82 | ALDH1A1 (0.52) | MAPTALDH1A1MEN1KMT2ANPC1 | |
| SCHEMBL10399649 | 0.82 | MAPT (0.68) | MAPTALDH1A1MEN1KMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4977178-A | Method of treating anxiety and depression with 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1990-12-11 | — | — | US | disclosed |
| US-4879391-A | 1-Phenyl-2(1H,3H)-indolone psychotherapeutic agents | PFIZER INC. (US) | 1989-11-07 | — | — | US | disclosed |
| US-4861880-A | 1-phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |
| EP-0104860-B1 | 1-PHENYL-2(1H,3H)-INDOLONE PSYCHO-THERAPEUTIC AGENTS | PFIZER INC. (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4476307-A | Heteroylidene indolone compounds | PFIZER INC. (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0104860-A1 | 1-Phenyl-2(1H,3H)-indolone psycho-therapeutic agents | PFIZER INC. (US) | 1984-04-04 | — | — | EP | disclosed |