⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5400223 | 1.00 | TSHR (0.56) | — | |
| SCHEMBL5944923 | 0.72 | TSHR (1.00) | — | |
| SCHEMBL22490 | 0.72 | — | — | |
| SCHEMBL5608675 | 0.72 | — | — | |
| SCHEMBL1707290 | 0.72 | — | — | |
| SCHEMBL16731979 | 0.72 | — | — | |
| SCHEMBL5789839 | 0.72 | — | — | |
| Dioxane SCHEMBL29065144 | 0.71 | — | — | |
| Tetraoxane SCHEMBL3273646 | 0.69 | TTR (0.36) | — | |
| SCHEMBL17180694 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 483 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250127755-A1 | PHARMACOLOGICAL DEPLETION OF HEME FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME | SCRIPPS RESEARCH INST (US) | 2025-04-24 | — | — | US | claimed |
| EP-4346803-A1 | ANTIMALARIAL ENDOPEROXIDE FOR THE TREATMENT OF MYELODYSPLASTIC SYNDROME | The Scripps Research Institute (US) | 2024-04-10 | — | — | EP | claimed |
| WO-2023146255-A1 | PEPTIDE TRANSPORTER INCLUDING HYDROPHOBIC STRUCTURE THAT BINDS TO ALBUMIN | 주식회사 메디치바이오 | 2023-08-03 | — | — | WO | claimed |
| US-20200377483-A1 | NEW ANTI-MALARIAL AGENT | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2020-12-03 | — | — | US | claimed |
| EP-3526214-A1 | NEW ANTI-MALARIAL AGENT | MMV Medicines for Malaria Venture (CH) | 2019-08-21 | — | — | EP | claimed |
| CN-109843876-A | New anti-malarial agents | MMV疟疾药物投资公司 | 2019-06-04 | — | — | CN | claimed |
| WO-2018069420-A1 | NEW ANTI-MALARIAL AGENT | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2018-04-19 | — | — | WO | claimed |
| EP-3309156-A1 | NEW ANTI-MALARIAL AGENTS | MMV Medicines for Malaria Venture (CH) | 2018-04-18 | — | — | EP | claimed |
| EP-1514871-B1 | Dispiro 1,2,4 - trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2015-10-21 | — | — | EP | claimed |
| US-9018402-B2 | Production and use of 1,2,4-trioxolane compounds, ozonides, with bleaching properties for the whitening of teeth, skin, and hair | Herman, Ross M. (US) | 2015-04-28 | — | — | US | claimed |
| EP-1414813-B1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES MALARIA VENTURE MMV (CH) | 2006-09-13 | — | — | EP | claimed |
| US-20050256185-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2005-11-17 | — | — | US | claimed |
| US-6906205-B2 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2005-06-14 | — | — | US | claimed |
| EP-1514871-A1 | Dispiro 1,2,4 - trioxolane antimalarials | Medicines for Malaria Venture (CH) | 2005-03-16 | — | — | EP | claimed |
| US-6825230-B2 | PEROXY COMPOUNDS SUCH AS ADAMANTANE-2-SPIRO-3'-8'-((1'S)-10'-CAMPHORSULFONYL)-1',2',4'-TRIOXA-8' -AZASPIRO(4.5) DECANE, USED FOR PROPHYLAXIS OF MALARIA OR SCHISTOSOMIASIS INFECTIONS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-11-30 | — | — | US | claimed |
| US-20040186168-A1 | Such as spiroadamantane on one side and 4-substituted spiro-cyclohexyl on other side; structurally simple, nontoxic, easy synthesis, potent parasiticides | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-09-23 | — | — | US | claimed |
| EP-1414813-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | Medicines for Malaria Venture (CH) | 2004-05-06 | — | — | EP | claimed |
| US-20040039008-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURES MMV (CH) | 2004-02-26 | — | — | US | claimed |
| WO-2003000676-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE (CH) | 2003-01-03 | — | — | WO | claimed |
| US-6486199-B1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURE MMV INTERNATIONAL CENTRE COINTRIN (CH) | 2002-11-26 | — | — | US | claimed |