Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.78 |
| ▸ | STING1 | Q86WV6 | 13/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10400717 | 0.98 | HDAC1 (0.80) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL20049489 | 0.87 | HDAC3 (0.64) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL10400707 | 0.84 | HDAC3 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1590372 | 0.83 | STING1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1589579 | 0.81 | STING1 (0.68) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL9204578 | 0.81 | STING1 (0.63) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL3060771 | 0.81 | HDAC3 (0.56) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL1590345 | 0.80 | STING1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL7106760 | 0.80 | STING1 (0.61) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| Hydrochloric Acid SCHEMBL4457221 | 0.79 | HDAC3 (0.55) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4929636-A | Positive inotrophic benzothiazole and benzothiophene compositions and method of use therefor | AKZO N.V. (NL) | 1990-05-29 | — | — | US | disclosed |
| EP-0158380-B1 | BENZOTHIAZOLE AND BENZOTHIOPHENE DERIVATIVES | AKZO N.V. (NL) | 1989-01-11 | — | — | EP | disclosed |
| US-4665206-A | Benzothiophene derivatives | AKZO N.V. (NL) | 1987-05-12 | — | — | US | disclosed |
| EP-0158380-A1 | Benzothiazole and benzothiophene derivatives | AKZO N.V. (NL) | 1985-10-16 | — | — | EP | disclosed |