SCHEMBL10401638

SCHEMBL10401638

N=C1NC(=O)c2ccc(Cl)cc21

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPOX P50336 1/20 0.70
CES1 P23141 2/20 0.48
TGM2 P21980 2/20 0.48
S100A4 P26447 2/20 0.48
MAOA P21397 2/20 0.47
MAOB P27338 2/20 0.47
RXFP1 Q9HBX9 2/20 0.45
PKM P14618 1/20 0.45
ATIC P31939 1/20 0.44
CHEK1 O14757 2/20 0.42
LRRK2 Q5S007 2/20 0.42
DAPK3 O43293 1/20 0.42
MAP4K4 O95819 1/20 0.42
RET P07949 1/20 0.42
PIM1 P11309 1/20 0.42
LTK P29376 1/20 0.42
GRK5 P34947 1/20 0.42
CSNK1A1 P48729 1/20 0.42
CDK8 P49336 1/20 0.42
PRKX P51817 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8726573 0.92 PPOX (0.70) PPOXCES1TGM2S100A4MAOA
4-Chloro-Phthalimide SCHEMBL30932877 0.83 PPOX (1.00) PPOXCES1TGM2S100A4MAOA
SCHEMBL5439659 0.83 PPOX (0.50) PPOXCES1TGM2S100A4CHEK1
4-Chloro-Phthalimide SCHEMBL658064 0.83 PPOX (1.00) PPOXCES1TGM2S100A4MAOA
4-Chloro-Phthalimide SCHEMBL31268124 0.81 PPOX (0.95) PPOXCES1TGM2S100A4MAOA
SCHEMBL14486961 0.78 PPOX (0.80) PPOXCES1TGM2S100A4MAOA
SCHEMBL3143957 0.77 CES1 (0.47) PPOXCES1TGM2MAOAMAOB
SCHEMBL21573560 0.76 ROS1 (0.49) PPOXMAOAMAOBLRRK2CDK5
4-Chloro-Phthalimide SCHEMBL27477784 0.73 PPOX (0.78) PPOXS100A4MAOAMAOBRXFP1
SCHEMBL31139641 0.72 CES1 (0.77) PPOXCES1TGM2MAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3569659-A1 BLACK ISOINDOLINONE PIGMENT AND COLORING AGENT Dainichiseika Color & Chemicals Mfg. Co., Ltd. (JP) 2019-11-20 EP disclosed
US-4946858-A ANTIDIABETIC AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1990-08-07 US disclosed
US-4900739-A ANTIDIABETIC AGENTS AMERICAN HOME PRODUCTS CORP. (US) 1990-02-13 US disclosed
US-4317929-A Tetraphenylketazines and isoindolinone pigments obtained therefrom CIBA-GEIGY CORPORATION (US) 1982-03-02 US disclosed
US-4239686-A Process for producing phthalimido derivatives ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1980-12-16 US disclosed
US-4237293-A COLORFAST SHADES OF YELLOW TO RED FOR PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4237286-A COLORING PLASTICS AND LACQUERS IN YELLOW TO RED SHADES CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4237292-A SHADES OF YELLOW TO RED FOR PLASTICS AND LACQUERS CIBA-GEIGY CORPORATION (US) 1980-12-02 US disclosed
US-4231931-A YELLOW TO RED HUES CIBA-GEIGY CORPORATION (US) 1980-11-04 US disclosed
US-4132708-A Metal complexes of azomethines and process for their manufacture CIBA-GEIGY CORPORATION (US) 1979-01-02 US disclosed
US-4111947-A DYES, PLASTICS, LACQUERS CIBA-GEIGY CORPORATION (US) 1978-09-05 US disclosed
US-4022770-A COLORING CIBA-GEIGY CORPORATION (US) 1977-05-10 US disclosed