PPOX

Protoporphyrinogen oxidase · P50336 · PPOX on Sugi Atlas →

13,155 patent compounds predicted against PPOX, 6,600 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL3371170	0.71	18/20
Acetone (SCHEMBL532802)	0.61	17/20
SCHEMBL901038	0.51	17/20
Oxadiazon (SCHEMBL2484674)	0.80	16/20
Oxadiazon (SCHEMBL4659772)	0.79	16/20
SCHEMBL39055	0.65	16/20
Oxadiazon (SCHEMBL38813)	1.00	14/20
Oxadiazon (SCHEMBL1068568)	1.00	14/20
Dimefuron (SCHEMBL68325)	0.47	14/20
SCHEMBL4077918	0.40	13/20
Pentoxazone (SCHEMBL38904)	0.51	12/20
SCHEMBL5712847	0.39	12/20
SCHEMBL3668708	0.78	11/20
SCHEMBL1535840	0.65	11/20
SCHEMBL203565	0.39	10/20
SCHEMBL3246917	0.75	9/20
SCHEMBL38427	0.51	8/20
SCHEMBL314005	0.51	8/20
Flumiciorac-Pentyl (SCHEMBL38955)	0.57	7/20
Flumipropyn (SCHEMBL38980)	0.54	6/20

Clinical trials — most relevant to PPOX by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel	PHASE4	UNKNOWN
COMS for Chronic Ulcers Treatment	PHASE4	RECRUITING
Porphozym in the Treatment of Acute Attacks in AIP	PHASE2/PHASE3	COMPLETED
PDT With Metvix 160 mg/g Cream Versus PDT With Placebo Cream in Participants With Primary Nodular Basal Call Carcinoma	PHASE3	COMPLETED
Role of Vitamin E in Gaucher Disease Patients	PHASE3	COMPLETED
Controlled Trial of Panhematin in Treatment of Acute Attacks of Porphyria	PHASE2	COMPLETED
Phase I/II Study of Heme Arginate and Tin Mesoporphyrin for Acute Porphyria	PHASE1/PHASE2	COMPLETED
Networked Drug REpurposing for Mechanism-based neuroPrOtection in Acute Ischaemic STROKE	PHASE2	UNKNOWN
Does Heme Oxygenase-1 Induction Ameliorate Cardiac Injury After Myocardial Infarction?	PHASE1/PHASE2	COMPLETED
Daylight Photodynamic Therapy for Actinic Keratosis	PHASE1	COMPLETED
Hemin in Healthy Subjects	PHASE1	COMPLETED
Nitrite Infusion Studies	PHASE1	COMPLETED
Transbroncheal Novel PDT Peripheral Lung Tumor Ablation With 5-ALA	nan	NOT_YET_RECRUITING
Effects of Fos Biomedical Device on Diabetes Risk Factors and Sleep Quality in Adults at Risk for Type 2 Diabetes	nan	COMPLETED
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder 2	nan	COMPLETED
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder	nan	COMPLETED
Light Exposure Patterns and Symptoms Among Patients With Erythropoietic Protoporphyria	nan	COMPLETED
A Feasibility Study: Assessing Photobiomodulation in Myalgic Encephalomyelitis	nan	UNKNOWN
Leg Ulcers Standards of Care Enhancement	nan	COMPLETED
Transcranial Photobiomodulation for the Treatment of Pediatric Depression	nan	WITHDRAWN
Mitochondrial Oxygen Measurement Variability in Critically Ill Patients (INOX Variability Study)	nan	COMPLETED
Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN	nan	COMPLETED
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Covid-19: Possible Role of Neutrophil Extracellular Traps	nan	UNKNOWN
Portable Measurement of Protoporphyrin IX in the Skin	nan	COMPLETED
Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD	nan	COMPLETED
Oxidative Stress Parameters, Trace Element and Quality of Life in Men Before and After Covid-19 Vaccines	nan	UNKNOWN
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy	nan	RECRUITING
Effectiveness of Low-level Laser Therapy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a PPOX binder may also engage these)

Protein	Name	Similarity
Q60HD5	—	1.000	Q60HD5 →
P56602	—	1.000	P56602 →
P51175	—	0.999	P51175 →
HDAC10	Polyamine deacetylase HDAC10	0.954	landscape →
Q501J2	—	0.951	Q501J2 →
E1BNQ4	—	0.951	E1BNQ4 →
Q53HV7	—	0.950	Q53HV7 →
Q923K4	—	0.950	Q923K4 →
Q3T0A0	—	0.950	Q3T0A0 →
Q8BZG5	—	0.949	Q8BZG5 →
Q8BNV1	—	0.949	Q8BNV1 →
P60487	—	0.949	P60487 →
Q9JLV6	—	0.949	Q9JLV6 →
Q59I47	—	0.949	Q59I47 →
Q8IVS8	—	0.948	Q8IVS8 →
Q0VGK3	—	0.948	Q0VGK3 →
Q8QZY2	—	0.948	Q8QZY2 →
O55240	—	0.947	O55240 →
Q2KJF7	—	0.947	Q2KJF7 →
Q32M88	—	0.947	Q32M88 →
Q9TUI8	—	0.947	Q9TUI8 →
Q6XQN1	—	0.947	Q6XQN1 →
Q8CC86	—	0.947	Q8CC86 →
Q8VD52	—	0.946	Q8VD52 →
F1NZI4	—	0.946	F1NZI4 →
Q8BP56	—	0.946	Q8BP56 →
Q6AYG0	—	0.946	Q6AYG0 →
Q865R1	—	0.945	Q865R1 →
A2AI05	—	0.945	A2AI05 →
PNKP	Bifunctional polynucleotide phosphatase/kinase	0.945	landscape →