Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.74 |
| ▸ | DRD3 | P35462 | 6/20 | 0.74 |
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401514 | 0.97 | DRD2 (0.74) | DRD2DRD3HTR1AMAPTHTR7 | |
| SCHEMBL10401903 | 0.96 | DRD2 (0.72) | DRD2DRD3HTR1AMAPTHTR7 | |
| SCHEMBL10401593 | 0.96 | DRD2 (0.72) | DRD2DRD3HTR1AMAPTHTR7 | |
| Hydrochloric Acid SCHEMBL10402126 | 0.95 | DRD2 (0.70) | DRD2DRD3HTR1AMAPTHTR7 | |
| SCHEMBL10401391 | 0.89 | DRD2 (0.70) | DRD2DRD3HTR1AHTR7 | |
| SCHEMBL314501 | 0.89 | DRD2 (0.74) | DRD2DRD3HTR1AHTR7SMN1; SMN2 | |
| SCHEMBL16463565 | 0.85 | DRD2 (1.00) | DRD2DRD3HTR1AHTR7HTR2A | |
| SCHEMBL10401898 | 0.84 | TP53 (0.60) | DRD2DRD3HTR1AMAPTALDH1A1 | |
| SCHEMBL10401848 | 0.83 | DRD2 (0.62) | DRD2DRD3HTR1AMAPTHTR7 | |
| SCHEMBL314986 | 0.82 | DRD2 (0.83) | DRD2DRD3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4960776-A | ANTIALLERGENS | A. H. ROBINS COMPANY, INC. (US) | 1990-10-02 | — | — | US | disclosed |
| EP-0277725-A2 | 4-Aryl-N-[2-(dialkylamino and heterocyclicamino) alkyl]-1-piperazinecarboxamides and their use as anti allergy agents | A.H. ROBINS COMPANY, INCORPORATED (US) | 1988-08-10 | — | — | EP | disclosed |