Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.57 |
| ▸ | F10 | P00742 | 2/20 | 0.56 |
| ▸ | PLG | P00747 | 2/20 | 0.56 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.56 |
| ▸ | F2 | P00734 | 1/20 | 0.56 |
| ▸ | PLAU | P00749 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 6/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.55 |
| ▸ | MMP2 | P08253 | 4/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.53 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8654561 | 0.89 | F2 (0.59) | F10PLGST14F2PLAU | |
| SCHEMBL8654566 | 0.89 | F2 (0.59) | F10PLGST14F2PLAU | |
| SCHEMBL10402436 | 0.89 | POLB (0.49) | LTA4HF10PLGST14F2 | |
| SCHEMBL8655052 | 0.89 | LTA4H (0.59) | LTA4HACEACE2 | |
| SCHEMBL8655055 | 0.89 | LTA4H (0.59) | LTA4HACEACE2 | |
| SCHEMBL10404568 | 0.88 | ACE (0.53) | F10PLGST14F2PLAU | |
| SCHEMBL6438372 | 0.88 | ACE (0.58) | LTA4HACEACE2 | |
| SCHEMBL6438368 | 0.88 | ACE (0.58) | LTA4HACEACE2 | |
| SCHEMBL8378226 | 0.88 | ACE (0.58) | LTA4HACEACE2 | |
| SCHEMBL15251747 | 0.86 | MEN1 (0.52) | LTA4HACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | claimed |
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0190852-A2 | Dipeptide derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1986-08-13 | — | — | EP | disclosed |