Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042350 | 0.90 | TRPV1 (0.82) | TRPV1 | |
| SCHEMBL1039230 | 0.89 | TRPV1 (0.81) | TRPV1 | |
| Amg-517 SCHEMBL1042780 | 0.89 | TRPV1 (1.00) | TRPV1 | |
| Amg-517 SCHEMBL29360942 | 0.89 | TRPV1 (1.00) | TRPV1 | |
| Amg-517 SCHEMBL29389509 | 0.89 | TRPV1 (1.00) | TRPV1 | |
| SCHEMBL1040601 | 0.89 | TRPV1 (0.80) | TRPV1 | |
| SCHEMBL4255931 | 0.88 | TRPV1 (0.69) | TRPV1 | |
| SCHEMBL5968285 | 0.88 | TRPV1 (0.79) | TRPV1 | |
| SCHEMBL1042449 | 0.87 | TRPV1 (0.85) | TRPV1 | |
| SCHEMBL3976566 | 0.87 | TRPV1 (0.67) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2270006-A1 | Pyridazine derivatives useful as vanilloid receptor ligands | Amgen, Inc (US) | 2011-01-05 | — | — | EP | disclosed |
| US-7332511-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-02-19 | — | — | US | disclosed |
| US-7332511-B2 | Vanilloid receptor ligands and their use in treatments | AMGEN INC. (US) | 2008-02-19 | — | — | US | disclosed |