SCHEMBL10404362

SCHEMBL10404362

CCOC(=O)c1cc(C(=O)CBr)c(=O)[nH]c1C(=O)OCC

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 8/20 0.57
MAPT P10636 4/20 0.57
LMNA P02545 3/20 0.57
L3MBTL1 Q9Y468 2/20 0.57
POLB P06746 4/20 0.54
GAA P10253 3/20 0.54
NPC1 O15118 1/20 0.54
KDM4E B2RXH2 8/20 0.46
KMT2A Q03164 5/20 0.46
HPGD P15428 2/20 0.45
MEN1 O00255 3/20 0.44
GLA P06280 1/20 0.44
ATM Q13315 1/20 0.44
PDE3B Q13370 1/20 0.41
PDE3A Q14432 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8832434 0.88 ALDH1A1 (0.73) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5901416 0.87 ALDH1A1 (0.77) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5901613 0.84 ALDH1A1 (0.56) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL8832560 0.84 GAA (0.75) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5902310 0.82 ALDH1A1 (0.54) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5901507 0.82 ALDH1A1 (0.54) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL10404663 0.82 ALDH1A1 (0.56) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5901921 0.81 ALDH1A1 (0.52) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL5901624 0.80 ALDH1A1 (0.51) ALDH1A1MAPTLMNAL3MBTL1POLB
SCHEMBL10404651 0.80 ALDH1A1 (0.57) ALDH1A1MAPTLMNAL3MBTL1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4920226-A FOR HERBICIDES AMERICAN CYANAMID (US) 1990-04-24 US disclosed
EP-0127883-B1 (2-Imidazolin-2-yl)thieno and furo(2,3-b) and (3,2-b) pyridines and intermediates for the preparation thereof, and use of said compounds as herbicidal agents. AMERICAN CYANAMID COMPANY (US) 1989-06-07 EP disclosed
EP-0133310-B1 IMIDAZOLIDINONES, AND IMIDAZOLIDINETHIONES, PROCESS FOR THE PREPARATION THEREOF, AND USE OF SAID COMPOUNDS AS HERBICIDAL AGENTS AMERICAN CYANAMID COMPANY (US) 1988-09-14 EP disclosed
EP-0277661-A1 Imidazopyrrolopyridines and condensed derivatives thereof useful in the preparation of herbicidal compounds AMERICAN CYANAMID COMPANY (US) 1988-08-10 EP disclosed
US-4752323-A (2-imidazolin-2-yl)thieno- and furo[2,3-b] and [3,2-b]pyridines and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1988-06-21 US disclosed
US-4701208-A Dihydroimidazopyrrolopyridine, quinoline, thieno- and furo[2,3-b]pyridine, dihydrothieno- and furo[2,3-b]-pyridine, thieno- and furo[3,2-b]pyridine and dihydrothieno- and furo[3,2-b]pyridine herbicides and method for preparation thereof AMERICAN CYANAMID COMPANY (US) 1987-10-20 US disclosed
US-4650514-A PRE- AND POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1987-03-17 US disclosed
US-4608079-A Imidazolidinones, and imidazolidinethiones, process and intermediates for the preparation thereof, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1986-08-26 US disclosed
EP-0133310-A1 Imidazolidinones, and imidazolidinethiones, process for the preparation thereof, and use of said compounds as herbicidal agents AMERICAN CYANAMID COMPANY (US) 1985-02-20 EP disclosed
EP-0133309-A1 Herbicides and method for the preparation thereof AMERICAN CYANAMID COMPANY (US) 1985-02-20 EP disclosed
EP-0127883-A2 (2-Imidazolin-2-yl)thieno and furo(2,3-b) and (3,2-b) pyridines and intermediates for the preparation thereof, and use of said compounds as herbicidal agents. AMERICAN CYANAMID COMPANY (US) 1984-12-12 EP disclosed