Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.49 |
| ▸ | PREP | P48147 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.46 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10404152 | 0.85 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL10404199 | 0.85 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL10404111 | 0.83 | SMN1; SMN2 (0.64) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL10403936 | 0.82 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL8654840 | 0.79 | PREP (0.71) | PREPSLC6A9 | |
| SCHEMBL8654838 | 0.79 | PREP (0.71) | PREPSLC6A9 | |
| SCHEMBL22209483 | 0.79 | PREP (0.52) | ACEPREPLMNA | |
| SCHEMBL10887424 | 0.78 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL10403618 | 0.77 | POLB (0.77) | POLBSMN1; SMN2ACELMNA | |
| SCHEMBL10058307 | 0.76 | ACE (0.61) | SMN1; SMN2ACELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | claimed |
| US-4187216-A | ELASTASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | claimed |
| US-4971993-A | HYPOTENSIVE DIPEPTIDES DERIVATIVES | AJINOMOTO CO., INC. (JP) | 1990-11-20 | — | — | US | disclosed |
| EP-0190852-A2 | Dipeptide derivatives and antihypertensive drugs containing them | AJINOMOTO CO., INC. (JP) | 1986-08-13 | — | — | EP | disclosed |
| US-4187216-A | ELASTASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1980-02-05 | — | — | US | disclosed |