SCHEMBL10407250

SCHEMBL10407250

CCOC(=O)c1cn(C2CC2)c2c(F)c(N3CC(NC(=O)C(F)(F)F)C3)c(F)cc2c1=O

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.56
KCNH2 Q12809 6/20 0.47
KDM4E B2RXH2 3/20 0.44
HPGD P15428 3/20 0.44
CYP2C19 P33261 1/20 0.44
ALDH1A1 P00352 3/20 0.44
POLB P06746 2/20 0.44
OPRM1 P35372 2/20 0.44
HSD17B10 Q99714 2/20 0.44
PRKD3 O94806 1/20 0.44
ALOX15 P16050 1/20 0.44
CLK2 P49760 1/20 0.44
CLK4 Q9HAZ1 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CHRM2 P08172 1/20 0.43
CHRM1 P11229 1/20 0.43
OPRD1 P41143 1/20 0.43
STAT3 P40763 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9668175 0.86 ADRB2 (0.60) ADRB2KCNH2KDM4EHPGDCYP2C19
SCHEMBL9276997 0.83 ADRB2 (0.55) ADRB2KCNH2KDM4EHPGDCYP2C19
SCHEMBL10914492 0.83 ADRB2 (0.58) ADRB2KCNH2KDM4EHPGDCYP2C19
SCHEMBL9668649 0.82 ADRB2 (0.57) ADRB2KCNH2KDM4EHPGDCYP2C19
SCHEMBL29492858 0.81 ADRB2 (0.68) ADRB2KCNH2KDM4EHPGDALDH1A1
SCHEMBL2844967 0.81 ADRB2 (0.68) ADRB2KCNH2KDM4EHPGDALDH1A1
Trifluoroacetic Acid SCHEMBL8741059 0.81 ADRB2 (0.51) ADRB2KCNH2KDM4EHPGDCYP2C19
Trifluoroacetic Acid SCHEMBL8741058 0.81 ADRB2 (0.51) ADRB2KCNH2KDM4EHPGDCYP2C19
SCHEMBL7131518 0.81 ADRB2 (0.59) ADRB2KCNH2KDM4EHPGDALDH1A1
SCHEMBL6784057 0.81 KCNH2 (0.66) ADRB2KCNH2KDM4EHPGDCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4927926-A BACTERICIDES LABORATORIOS DEL DR. ESTEVE S.A. (ES) 1990-05-22 US disclosed