ADRB2

Beta-2 adrenergic receptor · P07550 · ADRB2 on Sugi Atlas →

276,089 patent compounds predicted against ADRB2, 176,296 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Fenoterol (SCHEMBL5009)	1.00	20/20
Salmeterol (SCHEMBL4767)	1.00	19/20
Salmeterol (SCHEMBL4768)	1.00	19/20
Salmeterol (SCHEMBL18070)	1.00	19/20
Indacaterol (SCHEMBL48098)	1.00	19/20
Sibenadet (SCHEMBL48983)	1.00	18/20
Metaproterenol (SCHEMBL4270)	1.00	16/20
Metaproterenol (SCHEMBL4271)	1.00	16/20
Procaterol (SCHEMBL4632)	1.00	16/20
Procaterol (SCHEMBL4633)	1.00	16/20
Salmefamol (SCHEMBL18458)	0.67	16/20
Arbutamine (SCHEMBL40757)	0.60	16/20
Labetalol (SCHEMBL41230)	1.00	14/20
Metaproterenol (SCHEMBL41815)	0.83	14/20
Metaproterenol (SCHEMBL41816)	0.83	14/20
Labetalol (SCHEMBL4582)	1.00	13/20
Labetalol (SCHEMBL41231)	1.00	13/20
Amosulalol (SCHEMBL48933)	1.00	13/20
Oxprenolol (SCHEMBL16310)	1.00	12/20
Oxprenolol (SCHEMBL16311)	1.00	12/20

Clinical trials — most relevant to ADRB2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Cardiopulmonary Effect of Inhaled Beta-2-agonists on Adult Patients Born With Ventricular Septum Defects.	PHASE4	COMPLETED
Sympathetic Neurovascular Transduction: Role of Adrenergic Receptors and Sex Differences	PHASE4	RECRUITING
Reversal of Acute β-Blocker Induced Bronchoconstriction	PHASE4	COMPLETED
Clonidine vs. Dexmedetomidine in Agitated Delirium in Intensive Care Patients	PHASE4	UNKNOWN
Dexmedetomidine Versus Propofol in Vitreoretinal Surgery	PHASE4	COMPLETED
Dexmedetomidine and Outcomes of Cardiac Surgery (DOCS)	PHASE2/PHASE3	COMPLETED
A Study to Compare the Effects of Coreg CR and Coreg IR on Heart Function in Subjects With Stable Chronic Heart Failure	PHASE3	COMPLETED
Efficacy and Safety of Propranolol Versus Atenolol on the Proliferative Phase of Infantile Hemangioma	PHASE3	COMPLETED
Effect of Esmolol on Oxygenation Index in Patients With Acute Respiratory Distress Syndrome	PHASE3	RECRUITING
MELABLOCK: A Clinical Trial on the Efficacy and Safety of Propranolol 80 mg in Melanoma Patients	PHASE2/PHASE3	UNKNOWN
Effect of Remimazolam Sedation on Outcomes of Mechanically Ventilated Patients in the ICU	PHASE3	RECRUITING
Use of Dexmedetomidine to Improve Pain Control and Recovery After Laparocopic-Assisted Bowel Surgery in Adults	PHASE3	NOT_YET_RECRUITING
Analgesia After Laparoscopic Cholecystectomy	PHASE2	UNKNOWN
Adrenergic Blockers for Cardiac Changes in Early Parkinson's Disease (Protocol 53136)	PHASE2	ACTIVE_NOT_RECRUITING
Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries	PHASE2	NOT_YET_RECRUITING
Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation	PHASE1	ACTIVE_NOT_RECRUITING
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children	PHASE1	COMPLETED
Genetic Influences of Albuterol Response In Children With Bronchiolitis	nan	COMPLETED
Can Caudal Dexmedetomidine Provide Effective Analgesia?	nan	NOT_YET_RECRUITING
Influence of Genetic Polymorphisms on Ventricular Structure and Function in Patients With Single Ventricle Anatomy	nan	COMPLETED
Evaluating Long Acting Beta Agonists Used to Treat Asthma Among Those With Either Arg/Arg or Gly/Gly Genotypes	nan	COMPLETED
Influence of Nebivolol on Postmenopausal Women	nan	UNKNOWN
Renal Denervation in Patients With Chronic Heart Failure	nan	WITHDRAWN
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Effect of Time-restricted Eating on Catecholamine-sensitivity of Adipose Tissue in Obese Adults	nan	ACTIVE_NOT_RECRUITING
The Locus Coeruleus, Norepinephrine and Cognitive Aging	nan	ACTIVE_NOT_RECRUITING
Ultrasound Guided Rectus Sheath Block and Transversus Abdominis Plane Block	nan	COMPLETED
Add-on Salmeterol Versus Montelukast in Arg/Arg-16 Asthmatics	nan	COMPLETED
Oral Propranolol Improve Retinopathy of Prematurity Outcomes in Very Preterm Infants	nan	UNKNOWN
The Influence of Beta Blocker Therapy on the Hemodynamic Response to Inotrope Infusion in Patients With Acute Decompensated Heart Failure	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a ADRB2 binder may also engage these)

Protein	Name	Similarity
P10608	—	1.000	P10608 →
P54833	—	1.000	P54833 →
P04274	—	1.000	P04274 →
Q28044	—	1.000	Q28044 →
Q28997	—	1.000	Q28997 →
Q4KWL2	—	1.000	Q4KWL2 →
P18762	—	0.997	P18762 →
Q8K4Z4	—	0.997	Q8K4Z4 →
Q28509	—	0.997	Q28509 →
Q9TST5	—	0.996	Q9TST5 →
P18901	—	0.994	P18901 →
O42384	—	0.992	O42384 →
O70528	—	0.992	O70528 →
HTR4	5-hydroxytryptamine receptor 4	0.992	landscape →
P53452	—	0.991	P53452 →
P42288	—	0.991	P42288 →
P97288	—	0.991	P97288 →
P50130	—	0.991	P50130 →
O42574	—	0.990	O42574 →
DRD1	D(1A) dopamine receptor	0.990	landscape →
Q8UUY8	—	0.990	Q8UUY8 →
Q95136	—	0.990	Q95136 →
Q91175	—	0.989	Q91175 →
Q16950	—	0.988	Q16950 →
Q5IS72	—	0.988	Q5IS72 →
O73810	—	0.987	O73810 →
Q61616	—	0.987	Q61616 →
P53454	—	0.987	P53454 →
P42290	—	0.987	P42290 →
ADRA1A	Alpha-1A adrenergic receptor	0.987	landscape →