Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10407495 | 0.90 | SMN1; SMN2 (0.42) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL9829742 | 0.86 | SMN1; SMN2 (0.49) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL9829362 | 0.85 | SMN1; SMN2 (0.39) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL10407538 | 0.85 | HPGD (0.41) | SMN1; SMN2ALOX5TDP1CYP4F2CYP4A11 | |
| SCHEMBL10408297 | 0.85 | HPGD (0.41) | SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL10407580 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL10408046 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL9831313 | 0.83 | TDP1 (0.49) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 | |
| SCHEMBL9832157 | 0.82 | SMN1; SMN2 (0.60) | SMN1; SMN2ALOX5LTA4HCYP4F2CYP4A11 | |
| SCHEMBL9831853 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2ALOX5LTA4HTDP1CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |