Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9831732 | 0.89 | ALDH1A1 (0.40) | TDP1SMN1; SMN2ALOX5LMNALTA4H | |
| SCHEMBL9829742 | 0.85 | SMN1; SMN2 (0.49) | TDP1SMN1; SMN2ALOX5LMNALTA4H | |
| SCHEMBL9830077 | 0.84 | TSHR (0.43) | SMN1; SMN2LMNALTA4HMAPTKMT2A | |
| SCHEMBL9831726 | 0.84 | KEAP1 (0.44) | TDP1LMNALTA4HL3MBTL1POLB | |
| SCHEMBL10408046 | 0.83 | SMN1; SMN2 (0.47) | TDP1SMN1; SMN2ALOX5LTA4HPOLB | |
| SCHEMBL10407580 | 0.83 | SMN1; SMN2 (0.47) | TDP1SMN1; SMN2ALOX5LTA4HPOLB | |
| SCHEMBL10407366 | 0.83 | SMN1; SMN2 (0.47) | TDP1SMN1; SMN2ALOX5LTA4HPOLB | |
| SCHEMBL5465593 | 0.82 | TDP1 (0.56) | TDP1LMNAL3MBTL1POLBMAPT | |
| SCHEMBL10395082 | 0.82 | SMN1; SMN2 (0.39) | SMN1; SMN2ALOX5LMNALTA4HL3MBTL1 | |
| SCHEMBL3651761 | 0.82 | TDP1 (0.70) | TDP1SMN1; SMN2LMNAL3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0449989-A1 | 6,7 DIHYDROPYRROLO 3,4-c] PYRIDO 2,3-d] PYRIMIDINE DERIVATIVES | Sloan-Kettering Institute For Cancer Research (US) | 1991-10-09 | — | — | EP | disclosed |
| WO-1990007496-A1 | 6,7 DIHYDROPYRROLO[3,4-c] PYRIDO[2,3-d] PYRIMIDINE DERIVATIVES | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-07-12 | — | — | WO | disclosed |
| US-4925939-A | 6,7-dihydropyrrol[3,4-c]pyrido[2,3-d]pyrimidine derivatives | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 1990-05-15 | — | — | US | disclosed |